Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity

Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4(+) T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs and are involved in impairment of skeletal muscle...

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Detalles Bibliográficos
Autores principales: Rousseau, Anne-Sophie, Murdaca, Joseph, Le Menn, Gwenaëlle, Sibille, Brigitte, Wahli, Walter, Le Garf, Sébastien, Chinetti, Giulia, Neels, Jaap G., Mothe-Satney, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010153/
https://www.ncbi.nlm.nih.gov/pubmed/33815130
http://dx.doi.org/10.3389/fphys.2021.587753

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