Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in Mice

RTS,S is the leading malaria vaccine in development, but has demonstrated only moderate protective efficacy in clinical trials. RTS,S is a virus-like particle (VLP) that uses the human hepatitis B virus as scaffold to display the malaria sporozoite antigen, circumsporozoite protein (CSP). Particle f...

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Detalles Bibliográficos
Autores principales: Kurtovic, Liriye, Wetzel, David, Reiling, Linda, Drew, Damien R., Palmer, Catherine, Kouskousis, Betty, Hanssen, Eric, Wines, Bruce D., Hogarth, P. Mark, Suckow, Manfred, Jenzelewski, Volker, Piontek, Michael, Chan, Jo-Anne, Beeson, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010251/
https://www.ncbi.nlm.nih.gov/pubmed/33815393
http://dx.doi.org/10.3389/fimmu.2021.641421

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