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The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center

Novel recurrent fusion gene types such as zinc finger protein 384 (ZNF384) fusions have been identified in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with the application of next-generation sequencing technologies. However, the comprehensive large-scale clinical cohort study for clarify...

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Autores principales: Qin, Ya-Zhen, Jiang, Qian, Xu, Lan-Ping, Wang, Yu, Jiang, Hao, Dao, Feng-Ting, Chen, Wen-Min, Zhao, Xiao-Su, Liu, Yan-Rong, Zhang, Xiao-Hui, Liu, Kai-Yan, Huang, Xiao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010301/
https://www.ncbi.nlm.nih.gov/pubmed/33816270
http://dx.doi.org/10.3389/fonc.2021.632532
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author Qin, Ya-Zhen
Jiang, Qian
Xu, Lan-Ping
Wang, Yu
Jiang, Hao
Dao, Feng-Ting
Chen, Wen-Min
Zhao, Xiao-Su
Liu, Yan-Rong
Zhang, Xiao-Hui
Liu, Kai-Yan
Huang, Xiao-Jun
author_facet Qin, Ya-Zhen
Jiang, Qian
Xu, Lan-Ping
Wang, Yu
Jiang, Hao
Dao, Feng-Ting
Chen, Wen-Min
Zhao, Xiao-Su
Liu, Yan-Rong
Zhang, Xiao-Hui
Liu, Kai-Yan
Huang, Xiao-Jun
author_sort Qin, Ya-Zhen
collection PubMed
description Novel recurrent fusion gene types such as zinc finger protein 384 (ZNF384) fusions have been identified in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with the application of next-generation sequencing technologies. However, the comprehensive large-scale clinical cohort study for clarifying their prognostic significance remains scarce to date. A total of 242 consecutive adult Ph-negative BCP-ALL patients treated in our institute were retrospectively screened ZNF384 fusions at diagnosis by multiplex real time quantitative PCR. ZNF384 fusions were identified in 47 patients (19.4%) and all belonged to B-other ALL (having no high hyperdiploid karyotype, BCR-ABL1, TCF3-PBX1, ETV6-RUNX1, or MLL rearrangement). In the whole cohort, patients with ZNF384 fusions had significantly higher 3-year relapse-free-survival (RFS) and tended to have a higher 3-year overall survival (OS) than those with no ZNF384 fusions (80.1% vs. 52.5%, P = 0.013; 67.6% vs. 54.0%, P = 0.10). For patients receiving chemotherapy alone and received allogeneic-hematologic stem cell transplantation (allo-HSCT) were censored at the time of transplantation, patients with ZNF384 fusions had both similar RFS and similar OS to B-other ALL patients with no ZNF384 fusions (RFS: P =0.94 and 0.30; OS: P =0.94 and 0.51). For patients receiving transplantation, those with ZNF384 fusions had significantly higher 3-year RFS than B-other ALL patients with no ZNF384 fusions and their OS were similar (P = 0.022 and 0.24). Only two of 31 patients with ZNF384 fusions and receiving allo-HSCT relapsed, individually occurred 66.8 and 69.8 months after transplantation. Therefore, ZNF384 fusion is common in adult BCP-ALL, which may define a new group from BCP-ALL containing no classical fusion transcript with better prognosis through receiving allo-HSCT.
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spelling pubmed-80103012021-04-01 The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center Qin, Ya-Zhen Jiang, Qian Xu, Lan-Ping Wang, Yu Jiang, Hao Dao, Feng-Ting Chen, Wen-Min Zhao, Xiao-Su Liu, Yan-Rong Zhang, Xiao-Hui Liu, Kai-Yan Huang, Xiao-Jun Front Oncol Oncology Novel recurrent fusion gene types such as zinc finger protein 384 (ZNF384) fusions have been identified in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with the application of next-generation sequencing technologies. However, the comprehensive large-scale clinical cohort study for clarifying their prognostic significance remains scarce to date. A total of 242 consecutive adult Ph-negative BCP-ALL patients treated in our institute were retrospectively screened ZNF384 fusions at diagnosis by multiplex real time quantitative PCR. ZNF384 fusions were identified in 47 patients (19.4%) and all belonged to B-other ALL (having no high hyperdiploid karyotype, BCR-ABL1, TCF3-PBX1, ETV6-RUNX1, or MLL rearrangement). In the whole cohort, patients with ZNF384 fusions had significantly higher 3-year relapse-free-survival (RFS) and tended to have a higher 3-year overall survival (OS) than those with no ZNF384 fusions (80.1% vs. 52.5%, P = 0.013; 67.6% vs. 54.0%, P = 0.10). For patients receiving chemotherapy alone and received allogeneic-hematologic stem cell transplantation (allo-HSCT) were censored at the time of transplantation, patients with ZNF384 fusions had both similar RFS and similar OS to B-other ALL patients with no ZNF384 fusions (RFS: P =0.94 and 0.30; OS: P =0.94 and 0.51). For patients receiving transplantation, those with ZNF384 fusions had significantly higher 3-year RFS than B-other ALL patients with no ZNF384 fusions and their OS were similar (P = 0.022 and 0.24). Only two of 31 patients with ZNF384 fusions and receiving allo-HSCT relapsed, individually occurred 66.8 and 69.8 months after transplantation. Therefore, ZNF384 fusion is common in adult BCP-ALL, which may define a new group from BCP-ALL containing no classical fusion transcript with better prognosis through receiving allo-HSCT. Frontiers Media S.A. 2021-03-17 /pmc/articles/PMC8010301/ /pubmed/33816270 http://dx.doi.org/10.3389/fonc.2021.632532 Text en Copyright © 2021 Qin, Jiang, Xu, Wang, Jiang, Dao, Chen, Zhao, Liu, Zhang, Liu and Huang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Qin, Ya-Zhen
Jiang, Qian
Xu, Lan-Ping
Wang, Yu
Jiang, Hao
Dao, Feng-Ting
Chen, Wen-Min
Zhao, Xiao-Su
Liu, Yan-Rong
Zhang, Xiao-Hui
Liu, Kai-Yan
Huang, Xiao-Jun
The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center
title The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center
title_full The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center
title_fullStr The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center
title_full_unstemmed The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center
title_short The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center
title_sort prognostic significance of znf384 fusions in adult ph-negative b-cell precursor acute lymphoblastic leukemia: a comprehensive cohort study from a single chinese center
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010301/
https://www.ncbi.nlm.nih.gov/pubmed/33816270
http://dx.doi.org/10.3389/fonc.2021.632532
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