Cargando…

Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization

Background: Voriconazole is a potent antifungal drug with complex pharmacokinetics caused by time-dependent inhibition and polymorphisms of metabolizing enzymes. It also exhibits different pharmacokinetic characteristics between adults and children. An understanding of these alterations in pharmacok...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yahui, Zhao, Sixuan, Wang, Chuhui, Zhou, Pengxiang, Zhai, Suodi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010309/ https://www.ncbi.nlm.nih.gov/pubmed/33815119 http://dx.doi.org/10.3389/fphar.2021.636097

Ejemplares similares

Population Pharmacokinetic Modeling and Dose Optimization of Vancomycin in Chinese Patients with Augmented Renal Clearance
por: Zhao, Sixuan, et al.
Publicado: (2021)

Predicting the Outcome of Voriconazole Individualized Medication Using Integrated Pharmacokinetic/Pharmacodynamic Model
por: Yang, Ping, et al.
Publicado: (2021)

Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization
por: Li, SiChan, et al.
Publicado: (2022)

Dose Optimization of Vancomycin for Critically Ill Patients Undergoing CVVH: A Prospective Population PK/PD Analysis
por: Wang, Chuhui, et al.
Publicado: (2021)

Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis
por: Jiang, Zhiwen, et al.
Publicado: (2022)

Conbercept for Treatment of Neovascular Age-Related Macular Degeneration and Visual Impairment due to Diabetic Macular Edema or Pathologic Myopia Choroidal Neovascularization: A Systematic Review and Meta-Analysis
por: Zhou, Pengxiang, et al.
Publicado: (2021)

Inflammation Affects Liver Function and the Metabolism of Voriconazole to Voriconazole-N-Oxide in Adult and Elderly Patients
por: Liang, Zaiming, et al.
Publicado: (2022)

Pharmacokinetic interaction of voriconazole and clarithromycin in Pakistani healthy male volunteers: a single dose, randomized, crossover, open-label study
por: Mushtaq, Mehwish, et al.
Publicado: (2023)

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment
por: Ye, Lingling, et al.
Publicado: (2022)

The OBTAINS study: A nationwide cross-sectional survey on the implementation of extended or continuous infusion of β-lactams and vancomycin among neonatal sepsis patients in China
por: Zhou, Pengxiang, et al.
Publicado: (2022)

Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism
por: Schulz, Josefine, et al.
Publicado: (2022)

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates
por: Smits, Anne, et al.
Publicado: (2020)

Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors
por: Huang, Weize, et al.
Publicado: (2022)

Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients
por: Cheng, Lin, et al.
Publicado: (2023)

Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients
por: Zhang, Miao, et al.
Publicado: (2021)

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics
por: Adiwidjaja, Jeffry, et al.
Publicado: (2020)

Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics of Voriconazole and Development of a Voriconazole Dosing Optimization Model in Thai Patients with Hematologic Diseases
por: Khan-asa, Buddharat, et al.
Publicado: (2020)

Population Pharmacokinetics and Dose Optimization of Ganciclovir in Critically Ill Children
por: Li, SiChan, et al.
Publicado: (2021)

Factors Affecting Voriconazole Trough Concentration and Optimal Maintenance Voriconazole Dose in Chinese Children
por: Zhao, Yi-Chang, et al.
Publicado: (2021)

Population pharmacokinetics and initial dose optimization of tacrolimus in children with severe combined immunodeficiency undergoing hematopoietic stem cell transplantation
por: Chen, Xiao, et al.
Publicado: (2022)

Characterizing Pharmacokinetics in Children With Obesity—Physiological, Drug, Patient, and Methodological Considerations
por: Gerhart, Jacqueline G., et al.
Publicado: (2022)

Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing
por: Ali, Ali Mohamed, et al.
Publicado: (2018)

Developmental Population Pharmacokinetics and Dosing Optimization of Cefepime in Neonates and Young Infants
por: Zhao, Yang, et al.
Publicado: (2020)

Population Pharmacokinetics and Model-Based Dosing Optimization of Teicoplanin in Pediatric Patients
por: Zhang, Tao, et al.
Publicado: (2020)

Population pharmacokinetics and dosing optimization of unbound teicoplanin in Chinese adult patients
por: Fu, Wen-Qian, et al.
Publicado: (2022)

Physiologically-based pharmacokinetic modelling and dosing evaluation of gentamicin in neonates using PhysPK
por: Zazo, Hinojal, et al.
Publicado: (2022)

Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review.
por: Kim, Hannah Yejin, et al.
Publicado: (2020)

Physiologic and pharmacokinetic changes in pregnancy
por: Costantine, Maged M.
Publicado: (2014)

Effects of voriconazole on population pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic granulomatous disease undergoing hematopoietic stem cell transplantation
por: Chen, Xiao, et al.
Publicado: (2021)

Population pharmacokinetic analysis and dosing optimization of polymyxin B in critically ill patients
por: Liang, Danhong, et al.
Publicado: (2023)

Individualized Medication of Voriconazole: A Practice Guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society
por: Chen, Ken, et al.
Publicado: (2018)

Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug–Drug Interactions Involving Modafinil
por: Rowland, Angela, et al.
Publicado: (2016)

Population Pharmacokinetics of Caspofungin and Dosing Optimization in Children With Allogeneic Hematopoietic Stem Cell Transplantation
por: Niu, Chang-He, et al.
Publicado: (2020)

Population Pharmacokinetics of Antimalarial Naphthoquine in Combination with Artemisinin in Tanzanian Children and Adults: Dose Optimization
por: Ali, Ali Mohamed, et al.
Publicado: (2022)

Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing
por: Yow, Hui-Yin, et al.
Publicado: (2022)

Population pharmacokinetic analysis and dosing regimen optimization of teicoplanin in critically ill patients with sepsis
por: Chen, Chao‐Yang, et al.
Publicado: (2023)

Unraveling bisphenol A pharmacokinetics using physiologically based pharmacokinetic modeling
por: Yang, Xiaoxia, et al.
Publicado: (2015)

Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats
por: Shen, Jiquan, et al.
Publicado: (2020)

Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Starting from Pharmacokinetics in Rats and Human
por: Yang, Fen, et al.
Publicado: (2017)

Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling
por: Wu, Chunnuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g4pmia4ok36fp4mpblrdrc1cjj