Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement

A 61-year old lady with poorly-controlled type 2 diabetes mellitus was diagnosed with rhino-orbital-cerebral mucormycosis following presentation with sinusitis, ophthalmoplegia, proptosis and facial numbness. She was treated successfully with aggressive surgical intervention including orbital exente...

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Autores principales: Miller, R.P., Farrugia, L., Leask, J., Khalsa, K., Khanna, N., Melia, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010354/
https://www.ncbi.nlm.nih.gov/pubmed/33816097
http://dx.doi.org/10.1016/j.mmcr.2021.03.005
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author Miller, R.P.
Farrugia, L.
Leask, J.
Khalsa, K.
Khanna, N.
Melia, L.
author_facet Miller, R.P.
Farrugia, L.
Leask, J.
Khalsa, K.
Khanna, N.
Melia, L.
author_sort Miller, R.P.
collection PubMed
description A 61-year old lady with poorly-controlled type 2 diabetes mellitus was diagnosed with rhino-orbital-cerebral mucormycosis following presentation with sinusitis, ophthalmoplegia, proptosis and facial numbness. She was treated successfully with aggressive surgical intervention including orbital exenteration, accompanied by anti-fungal therapy with liposomal amphotericin B and posaconazole, followed by isavuconazole as salvage therapy. We discuss the challenges around optimising antifungal therapy of this lethal infection in the context of hepatic and renal toxicity.
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spelling pubmed-80103542021-04-01 Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement Miller, R.P. Farrugia, L. Leask, J. Khalsa, K. Khanna, N. Melia, L. Med Mycol Case Rep Case Report A 61-year old lady with poorly-controlled type 2 diabetes mellitus was diagnosed with rhino-orbital-cerebral mucormycosis following presentation with sinusitis, ophthalmoplegia, proptosis and facial numbness. She was treated successfully with aggressive surgical intervention including orbital exenteration, accompanied by anti-fungal therapy with liposomal amphotericin B and posaconazole, followed by isavuconazole as salvage therapy. We discuss the challenges around optimising antifungal therapy of this lethal infection in the context of hepatic and renal toxicity. Elsevier 2021-03-17 /pmc/articles/PMC8010354/ /pubmed/33816097 http://dx.doi.org/10.1016/j.mmcr.2021.03.005 Text en © 2021 The Authors. Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Miller, R.P.
Farrugia, L.
Leask, J.
Khalsa, K.
Khanna, N.
Melia, L.
Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
title Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
title_full Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
title_fullStr Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
title_full_unstemmed Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
title_short Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
title_sort successful treatment of rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010354/
https://www.ncbi.nlm.nih.gov/pubmed/33816097
http://dx.doi.org/10.1016/j.mmcr.2021.03.005
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