Prediction of CRISPR/Cas9 single guide RNA cleavage efficiency and specificity by attention-based convolutional neural networks

CRISPR/Cas9 is a preferred genome editing tool and has been widely adapted to ranges of disciplines, from molecular biology to gene therapy. A key prerequisite for the success of CRISPR/Cas9 is its capacity to distinguish between single guide RNAs (sgRNAs) on target and homologous off-target sites....

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Detalles Bibliográficos
Autores principales: Zhang, Guishan, Zeng, Tian, Dai, Zhiming, Dai, Xianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010402/
https://www.ncbi.nlm.nih.gov/pubmed/33841753
http://dx.doi.org/10.1016/j.csbj.2021.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010402/
https://www.ncbi.nlm.nih.gov/pubmed/33841753
http://dx.doi.org/10.1016/j.csbj.2021.03.001

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