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Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer
Trophoblast cell-surface antigen 2 (TROP2) is a transmembrane glycoprotein expressed in epithelial cells. Increased TROP2 expression has been reported to be associated with malignant progression in most carcinomas; however, TROP2 has a tumor-suppressive function in certain types of cancer. Since the...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010512/ https://www.ncbi.nlm.nih.gov/pubmed/33815794 http://dx.doi.org/10.3892/mco.2021.2267 |
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author | Kushiyama, Shuhei Yashiro, Masakazu Yamamoto, Yurie Sera, Tomohiro Sugimoto, Atsushi Nishimura, Sadaaki Togano, Shingo Kuroda, Kenji Yoshii, Mami Tamura, Tatsuro Toyokawa, Takahiro Tanaka, Hiroaki Muguruma, Kazuya Nakada, Hiroshi Ohira, Masaichi |
author_facet | Kushiyama, Shuhei Yashiro, Masakazu Yamamoto, Yurie Sera, Tomohiro Sugimoto, Atsushi Nishimura, Sadaaki Togano, Shingo Kuroda, Kenji Yoshii, Mami Tamura, Tatsuro Toyokawa, Takahiro Tanaka, Hiroaki Muguruma, Kazuya Nakada, Hiroshi Ohira, Masaichi |
author_sort | Kushiyama, Shuhei |
collection | PubMed |
description | Trophoblast cell-surface antigen 2 (TROP2) is a transmembrane glycoprotein expressed in epithelial cells. Increased TROP2 expression has been reported to be associated with malignant progression in most carcinomas; however, TROP2 has a tumor-suppressive function in certain types of cancer. Since the function of TROP2 is controversial, the present study subsequently aimed to clarify the clinicopathologic significance of TROP2 and pTROP2 expression in human gastric cancer (GC). The cases of 704 patients with GC who underwent gastrectomy were retrospectively analyzed. The expression levels of TROP2 and pTROP2 in each tumor were evaluated by immunohistochemistry. The association between the clinicopathologic features of patients with GC and the levels of TROP2 and pTROP2 in their tumors was analyzed. Increased TROP2 and pTROP2 expression was identified in 330 (46.9%) and 306 (43.5%) of the 704 patients with GC, respectively. Increased TROP2 expression was associated with the histological intestinal type, high tumor invasion depth (T3/T4), lymph node metastasis, lymphatic invasion and venous invasion. By contrast, increased pTROP2 expression was associated with intestinal type, low tumor invasion depth (T1/2), no lymph node metastasis and no lymphatic invasion. Increased TROP2 expression was associated with poorer overall survival (OS) (P<0.01; log rank test), whereas increased pTROP2 expression was significantly associated with improved OS (P<0.01; log rank test). In conclusion, increased expression levels of TROP2, but not pTROP2, may be associated with the metastatic ability of GC, resulting in poor prognosis of patients with GC. |
format | Online Article Text |
id | pubmed-8010512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-80105122021-04-01 Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer Kushiyama, Shuhei Yashiro, Masakazu Yamamoto, Yurie Sera, Tomohiro Sugimoto, Atsushi Nishimura, Sadaaki Togano, Shingo Kuroda, Kenji Yoshii, Mami Tamura, Tatsuro Toyokawa, Takahiro Tanaka, Hiroaki Muguruma, Kazuya Nakada, Hiroshi Ohira, Masaichi Mol Clin Oncol Articles Trophoblast cell-surface antigen 2 (TROP2) is a transmembrane glycoprotein expressed in epithelial cells. Increased TROP2 expression has been reported to be associated with malignant progression in most carcinomas; however, TROP2 has a tumor-suppressive function in certain types of cancer. Since the function of TROP2 is controversial, the present study subsequently aimed to clarify the clinicopathologic significance of TROP2 and pTROP2 expression in human gastric cancer (GC). The cases of 704 patients with GC who underwent gastrectomy were retrospectively analyzed. The expression levels of TROP2 and pTROP2 in each tumor were evaluated by immunohistochemistry. The association between the clinicopathologic features of patients with GC and the levels of TROP2 and pTROP2 in their tumors was analyzed. Increased TROP2 and pTROP2 expression was identified in 330 (46.9%) and 306 (43.5%) of the 704 patients with GC, respectively. Increased TROP2 expression was associated with the histological intestinal type, high tumor invasion depth (T3/T4), lymph node metastasis, lymphatic invasion and venous invasion. By contrast, increased pTROP2 expression was associated with intestinal type, low tumor invasion depth (T1/2), no lymph node metastasis and no lymphatic invasion. Increased TROP2 expression was associated with poorer overall survival (OS) (P<0.01; log rank test), whereas increased pTROP2 expression was significantly associated with improved OS (P<0.01; log rank test). In conclusion, increased expression levels of TROP2, but not pTROP2, may be associated with the metastatic ability of GC, resulting in poor prognosis of patients with GC. D.A. Spandidos 2021-05 2021-03-19 /pmc/articles/PMC8010512/ /pubmed/33815794 http://dx.doi.org/10.3892/mco.2021.2267 Text en Copyright: © Kushiyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Kushiyama, Shuhei Yashiro, Masakazu Yamamoto, Yurie Sera, Tomohiro Sugimoto, Atsushi Nishimura, Sadaaki Togano, Shingo Kuroda, Kenji Yoshii, Mami Tamura, Tatsuro Toyokawa, Takahiro Tanaka, Hiroaki Muguruma, Kazuya Nakada, Hiroshi Ohira, Masaichi Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer |
title | Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer |
title_full | Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer |
title_fullStr | Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer |
title_full_unstemmed | Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer |
title_short | Clinicopathologic significance of TROP2 and phospho-TROP2 in gastric cancer |
title_sort | clinicopathologic significance of trop2 and phospho-trop2 in gastric cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010512/ https://www.ncbi.nlm.nih.gov/pubmed/33815794 http://dx.doi.org/10.3892/mco.2021.2267 |
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