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Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis

INTRODUCTION AND IMPORTANCE: Aggressive angiomyxoma is characterized as a non-capsulated soft mass with the ability to progress to surrounding tissues but without metastasis to distant tissues. Slowing tumor extension leading delayed tumor diagnosis, expression of different types of hormonal recepto...

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Autores principales: Akhavan, Setareh, Nikfar, Somayeh, Behboudi, Behnam, Malek, Mahrooz, Saffar, Hana, Zamani, Narges
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010639/
https://www.ncbi.nlm.nih.gov/pubmed/33752033
http://dx.doi.org/10.1016/j.ijscr.2021.105756
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author Akhavan, Setareh
Nikfar, Somayeh
Behboudi, Behnam
Malek, Mahrooz
Saffar, Hana
Zamani, Narges
author_facet Akhavan, Setareh
Nikfar, Somayeh
Behboudi, Behnam
Malek, Mahrooz
Saffar, Hana
Zamani, Narges
author_sort Akhavan, Setareh
collection PubMed
description INTRODUCTION AND IMPORTANCE: Aggressive angiomyxoma is characterized as a non-capsulated soft mass with the ability to progress to surrounding tissues but without metastasis to distant tissues. Slowing tumor extension leading delayed tumor diagnosis, expression of different types of hormonal receptors, therapeutic ineffectiveness of noninvasive treatment approaches and misdiagnosis have remained as the major challenges for managing this tumor. CASE PRESENTATION: Herein, we described a case of aggressive angiomyxoma located in the posterior of the uterus and vagina that as successfully managed surgically to remove tumor mass followed by gonadotropin-releasing hormone (GnRH) agonist to prevent tumor recurrence. CLINICAL DISCUSSION: Surgical resection is the treatment of choice in aggressive angiomyxoma with complete success rate, however despite such successfulness, about two-thirds of patients experienced postoperative recurrence rate that could be prevented by hormone-based therapy especially GnRH agonist. CONCLUSION: Aggressive angiomyxoma is a rare tumor with locally invasive behavior. As misdiagnosis is common imaging like MRI with DWI should be considered. The best treatment is surgical resection by experienced surgeons in tertiary referral hospitals. Even with complete resection, the recurrence rate is high. So adjuvant medical treatment seems to be necessary.
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spelling pubmed-80106392021-04-02 Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis Akhavan, Setareh Nikfar, Somayeh Behboudi, Behnam Malek, Mahrooz Saffar, Hana Zamani, Narges Int J Surg Case Rep Case Report INTRODUCTION AND IMPORTANCE: Aggressive angiomyxoma is characterized as a non-capsulated soft mass with the ability to progress to surrounding tissues but without metastasis to distant tissues. Slowing tumor extension leading delayed tumor diagnosis, expression of different types of hormonal receptors, therapeutic ineffectiveness of noninvasive treatment approaches and misdiagnosis have remained as the major challenges for managing this tumor. CASE PRESENTATION: Herein, we described a case of aggressive angiomyxoma located in the posterior of the uterus and vagina that as successfully managed surgically to remove tumor mass followed by gonadotropin-releasing hormone (GnRH) agonist to prevent tumor recurrence. CLINICAL DISCUSSION: Surgical resection is the treatment of choice in aggressive angiomyxoma with complete success rate, however despite such successfulness, about two-thirds of patients experienced postoperative recurrence rate that could be prevented by hormone-based therapy especially GnRH agonist. CONCLUSION: Aggressive angiomyxoma is a rare tumor with locally invasive behavior. As misdiagnosis is common imaging like MRI with DWI should be considered. The best treatment is surgical resection by experienced surgeons in tertiary referral hospitals. Even with complete resection, the recurrence rate is high. So adjuvant medical treatment seems to be necessary. Elsevier 2021-03-14 /pmc/articles/PMC8010639/ /pubmed/33752033 http://dx.doi.org/10.1016/j.ijscr.2021.105756 Text en © 2021 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Akhavan, Setareh
Nikfar, Somayeh
Behboudi, Behnam
Malek, Mahrooz
Saffar, Hana
Zamani, Narges
Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis
title Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis
title_full Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis
title_fullStr Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis
title_full_unstemmed Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis
title_short Aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis
title_sort aggressive angiomyxoma of the pelvis surgical management in a case with delayed diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010639/
https://www.ncbi.nlm.nih.gov/pubmed/33752033
http://dx.doi.org/10.1016/j.ijscr.2021.105756
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