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Case Report: Paratesticular Rhabdomyosarcoma
Paratesticular rhabdomyosarcoma (RMS) accounts for only 7% of all the RMS cases. Due to the limited available data, there is no consensus on the diagnosis and management of the paratesticular tumors. Here, we interrogated two paratesticular RMS cases in 25 and 27-year-old men presenting with painles...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010692/ https://www.ncbi.nlm.nih.gov/pubmed/33816267 http://dx.doi.org/10.3389/fonc.2021.629878 |
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author | Zhu, Yiyi Zhu, Ziwei Xiao, Yunyuan Zhu, Zaisheng |
author_facet | Zhu, Yiyi Zhu, Ziwei Xiao, Yunyuan Zhu, Zaisheng |
author_sort | Zhu, Yiyi |
collection | PubMed |
description | Paratesticular rhabdomyosarcoma (RMS) accounts for only 7% of all the RMS cases. Due to the limited available data, there is no consensus on the diagnosis and management of the paratesticular tumors. Here, we interrogated two paratesticular RMS cases in 25 and 27-year-old men presenting with painless and rapidly growing mass in the scrotum. Whereas the data showed no upregulation of tumor markers such as β-human chorionic gonadotropin (β-HCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH), scrotal ultrasonography and magnetic resonance imaging indicated the existence of paratesticular and inguinal lesions respectively. There was local recurrence in one patient who underwent radical orchiectomy for the sarcoma one year ago. In addition, the CT scans showed no occurrence of distant metastasis. The two patients underwent radical inguinal orchiectomy or resection of the recurrent tumors with nerve-sparing retroperitoneal lymph node dissection. Histologic examination revealed embryonal RMS (eRMS) without lymph node metastasis. We highlight the importance of multi-disciplinary participation for paratesticular RMS detection and preoperative ultrasound-guided needle biopsy (UNB) for rapid confirmatory diagnosis. Complete surgical resection coupled with chemotherapy and radiotherapy is the main treatment option for the paratesticular RMS. In addition, sperm cryopreservation treatment and endocrine follow-up could increase the overall survival and quality of life of the patients. |
format | Online Article Text |
id | pubmed-8010692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80106922021-04-01 Case Report: Paratesticular Rhabdomyosarcoma Zhu, Yiyi Zhu, Ziwei Xiao, Yunyuan Zhu, Zaisheng Front Oncol Oncology Paratesticular rhabdomyosarcoma (RMS) accounts for only 7% of all the RMS cases. Due to the limited available data, there is no consensus on the diagnosis and management of the paratesticular tumors. Here, we interrogated two paratesticular RMS cases in 25 and 27-year-old men presenting with painless and rapidly growing mass in the scrotum. Whereas the data showed no upregulation of tumor markers such as β-human chorionic gonadotropin (β-HCG), alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH), scrotal ultrasonography and magnetic resonance imaging indicated the existence of paratesticular and inguinal lesions respectively. There was local recurrence in one patient who underwent radical orchiectomy for the sarcoma one year ago. In addition, the CT scans showed no occurrence of distant metastasis. The two patients underwent radical inguinal orchiectomy or resection of the recurrent tumors with nerve-sparing retroperitoneal lymph node dissection. Histologic examination revealed embryonal RMS (eRMS) without lymph node metastasis. We highlight the importance of multi-disciplinary participation for paratesticular RMS detection and preoperative ultrasound-guided needle biopsy (UNB) for rapid confirmatory diagnosis. Complete surgical resection coupled with chemotherapy and radiotherapy is the main treatment option for the paratesticular RMS. In addition, sperm cryopreservation treatment and endocrine follow-up could increase the overall survival and quality of life of the patients. Frontiers Media S.A. 2021-03-17 /pmc/articles/PMC8010692/ /pubmed/33816267 http://dx.doi.org/10.3389/fonc.2021.629878 Text en Copyright © 2021 Zhu, Zhu, Xiao and Zhu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zhu, Yiyi Zhu, Ziwei Xiao, Yunyuan Zhu, Zaisheng Case Report: Paratesticular Rhabdomyosarcoma |
title | Case Report: Paratesticular Rhabdomyosarcoma |
title_full | Case Report: Paratesticular Rhabdomyosarcoma |
title_fullStr | Case Report: Paratesticular Rhabdomyosarcoma |
title_full_unstemmed | Case Report: Paratesticular Rhabdomyosarcoma |
title_short | Case Report: Paratesticular Rhabdomyosarcoma |
title_sort | case report: paratesticular rhabdomyosarcoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010692/ https://www.ncbi.nlm.nih.gov/pubmed/33816267 http://dx.doi.org/10.3389/fonc.2021.629878 |
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