Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity

Dopamine transporter (DAT) mediates the reuptake of synaptically released dopamine, and thus controls the duration and intensity of dopamine neurotransmission. Mammalian DAT has been observed to form oligomers, although the mechanisms of oligomerization and its role in DAT activity and trafficking r...

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Detalles Bibliográficos
Autores principales: Sorkina, Tatiana, Cheng, Mary Hongying, Bagalkot, Tarique R., Wallace, Callen, Watkins, Simon C., Bahar, Ivet, Sorkin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010718/
https://www.ncbi.nlm.nih.gov/pubmed/33610553
http://dx.doi.org/10.1016/j.jbc.2021.100430

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