Cargando…

TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform

Mostrar otras versiones (1)

The COVID-19 pandemic has highlighted the need for new antiviral targets, as many of the currently approved drugs have proven ineffective against mitigating SARS-CoV-2 infections. The host transmembrane serine protease TMPRSS2 is a highly promising antiviral target, as it plays a direct role in prim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peiffer, Amanda L., Garlick, Julie M., Wu, Yujin, Soellner, Matthew B., Brooks, Charles L., Mapp, Anna K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010734/ https://www.ncbi.nlm.nih.gov/pubmed/33791707 http://dx.doi.org/10.1101/2021.03.22.436465

Ejemplares similares

TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform
por: Peiffer, Amanda L., et al.
Publicado: (2023)

Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states
por: Peiffer, Amanda L., et al.
Publicado: (2022)

Discovery of TMPRSS2 inhibitors from virtual screening
por: Hu, Xin, et al.
Publicado: (2021)

In Silico Screening of Novel TMPRSS2 Inhibitors for Treatment of COVID-19
por: Wang, Shuo, et al.
Publicado: (2022)

Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19
por: Hu, Xin, et al.
Publicado: (2021)

In-silico screening for identification of potential inhibitors against SARS-CoV-2 transmembrane serine protease 2 (TMPRSS2)
por: Barge, Sagar, et al.
Publicado: (2021)

Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors
por: Mahmudpour, Mehdi, et al.
Publicado: (2021)

Discovery of novel TMPRSS2 inhibitors for COVID-19 using in silico fragment-based drug design, molecular docking, molecular dynamics, and quantum mechanics studies
por: Alzain, Abdulrahim A., et al.
Publicado: (2022)

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19
por: Shrimp, Jonathan H., et al.
Publicado: (2020)

SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study
por: Baby, Krishnaprasad, et al.
Publicado: (2021)

Discovery of Selective Inhibitors Against EBNA1 via High Throughput In Silico Virtual Screening
por: Li, Ning, et al.
Publicado: (2010)

Discovery of Specific Inhibitors for Intestinal E. coli β-Glucuronidase through In Silico Virtual Screening
por: Cheng, Ta-Chun, et al.
Publicado: (2015)

Combination of Virtual Screening Protocol by in Silico toward the Discovery of Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors
por: Fu, Ying, et al.
Publicado: (2018)

An in silico platform for predicting, screening and designing of antihypertensive peptides
por: Kumar, Ravi, et al.
Publicado: (2015)

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
por: Zhao, Yaxue, et al.
Publicado: (2014)

GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems
por: Iancu, Cristina V., et al.
Publicado: (2022)

Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
por: Miller, Ryan A., et al.
Publicado: (2018)

In silico virtual screening approaches for anti-viral drug discovery
por: Murgueitio, Manuela S., et al.
Publicado: (2012)

Identification of Inhibitors against Metastasis Protein “Survivin:” In silico Discovery Using Virtual Screening and Molecular Docking Studies
por: Mishra, Swechha, et al.
Publicado: (2017)

In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease
por: Xiong, Muya, et al.
Publicado: (2022)

Discovery of novel acetylcholinesterase inhibitors through integration of machine learning with genetic algorithm based in silico screening approaches
por: Khan, Mohd Imran, et al.
Publicado: (2023)

In silico screening of 393 mutants facilitates enzyme engineering of amidase activity in CalB
por: Hediger, Martin R., et al.
Publicado: (2013)

Evaluating Known Zika Virus NS2B-NS3 Protease Inhibitor Scaffolds via In Silico Screening and Biochemical Assays
por: Santos, Lucianna H., et al.
Publicado: (2023)

Auto In Silico Ligand Directing Evolution to Facilitate the Rapid and Efficient Discovery of Drug Lead
por: Wu, Fengxu, et al.
Publicado: (2020)

Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease
por: Stevaert, Annelies, et al.
Publicado: (2022)

Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform
por: Cao, Liangxian, et al.
Publicado: (2016)

An efficient T-cell epitope discovery strategy using in silico prediction and the iTopia assay platform
por: Fridman, Arthur, et al.
Publicado: (2012)

Promises and caveats of in silico biomarker discovery
por: Pusztai, L, et al.
Publicado: (2008)

In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking
por: Pu, Yinglan, et al.
Publicado: (2017)

Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches
por: Hwang, Jayeong, et al.
Publicado: (2021)

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery
por: Ghanem, Moustafa S., et al.
Publicado: (2022)

Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach
por: Hosseini, Faezeh Sadat, et al.
Publicado: (2022)

Prostate cancer genes associated with TMPRSS2–ERG gene fusion and prognostic of biochemical recurrence in multiple cohorts
por: Barwick, B G, et al.
Publicado: (2010)

Discovery of diminazene as a dual inhibitor of SARS-CoV-2 human host proteases TMPRSS2 and furin using cell-based assays
por: Xu, Ya-Ming, et al.
Publicado: (2022)

Pharmacophore modeling, in silico screening, molecular docking and molecular dynamics approaches for potential alpha-delta bungarotoxin-4 inhibitors discovery
por: Kumar, R. Barani, et al.
Publicado: (2015)

Discovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay
por: Liao, Chenzeng, et al.
Publicado: (2015)

Discovery of novel low-molecular-weight HIV-1 inhibitors interacting with cyclophilin A using in silico screening and biological evaluations
por: Tian, Yu-Shi, et al.
Publicado: (2012)

TMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells
por: Shi, Wen, et al.
Publicado: (2017)

In Silico-Based High-Throughput Screen for Discovery of Novel Combinations for Tuberculosis Treatment
por: Singh, Ragini, et al.
Publicado: (2015)

Towards the routine use of in silico screenings for drug discovery using metabolic modelling
por: Bintener, Tamara, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tv8ihpios912glf1etoba0a1rm