TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform

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The COVID-19 pandemic has highlighted the need for new antiviral targets, as many of the currently approved drugs have proven ineffective against mitigating SARS-CoV-2 infections. The host transmembrane serine protease TMPRSS2 is a highly promising antiviral target, as it plays a direct role in prim...

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Detalles Bibliográficos
Autores principales: Peiffer, Amanda L., Garlick, Julie M., Wu, Yujin, Soellner, Matthew B., Brooks, Charles L., Mapp, Anna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010734/
https://www.ncbi.nlm.nih.gov/pubmed/33791707
http://dx.doi.org/10.1101/2021.03.22.436465
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