Cargando…
A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
SARS-CoV-2 infection has caused a lasting global pandemic costing millions of lives and untold additional costs. Understanding the immune response to SARS-CoV-2 has been one of the main challenges in the past year in order to decipher mechanisms of host responses and interpret disease pathogenesis....
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010752/ https://www.ncbi.nlm.nih.gov/pubmed/33791720 http://dx.doi.org/10.1101/2021.03.25.21254376 |
_version_ | 1783673119444041728 |
---|---|
author | Vick, Sarah C. Frutoso, Marie Mair, Florian Konecny, Andrew J. Greene, Evan Wolf, Caitlin R. Logue, Jennifer K. Boonyaratanakornkit, Jim Gottardo, Raphael Schiffer, Joshua T. Chu, Helen Y. Prlic, Martin Lund, Jennifer M. |
author_facet | Vick, Sarah C. Frutoso, Marie Mair, Florian Konecny, Andrew J. Greene, Evan Wolf, Caitlin R. Logue, Jennifer K. Boonyaratanakornkit, Jim Gottardo, Raphael Schiffer, Joshua T. Chu, Helen Y. Prlic, Martin Lund, Jennifer M. |
author_sort | Vick, Sarah C. |
collection | PubMed |
description | SARS-CoV-2 infection has caused a lasting global pandemic costing millions of lives and untold additional costs. Understanding the immune response to SARS-CoV-2 has been one of the main challenges in the past year in order to decipher mechanisms of host responses and interpret disease pathogenesis. Comparatively little is known in regard to how the immune response against SARS-CoV-2 differs from other respiratory infections. In our study, we compare the peripheral blood immune signature from SARS-CoV-2 infected patients to patients hospitalized pre-pandemic with Influenza Virus or Respiratory Syncytial Virus (RSV). Our in-depth profiling indicates that the immune landscape in patients infected by SARS-CoV-2 is largely similar to patients hospitalized with Flu or RSV. Similarly, serum cytokine and chemokine expression patterns were largely overlapping. Unique to patients infected with SARS-CoV-2 who had the most critical clinical disease state were changes in the regulatory T cell (Treg) compartment. A Treg signature including increased frequency, activation status, and migration markers was correlated with the severity of COVID-19 disease. These findings are particularly relevant as Tregs are being discussed as a therapy to combat the severe inflammation seen in COVID-19 patients. Likewise, having defined the overlapping immune landscapes in SARS-CoV-2, existing knowledge of Flu and RSV infections could be leveraged to identify common treatment strategies. |
format | Online Article Text |
id | pubmed-8010752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-80107522021-04-01 A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections Vick, Sarah C. Frutoso, Marie Mair, Florian Konecny, Andrew J. Greene, Evan Wolf, Caitlin R. Logue, Jennifer K. Boonyaratanakornkit, Jim Gottardo, Raphael Schiffer, Joshua T. Chu, Helen Y. Prlic, Martin Lund, Jennifer M. medRxiv Article SARS-CoV-2 infection has caused a lasting global pandemic costing millions of lives and untold additional costs. Understanding the immune response to SARS-CoV-2 has been one of the main challenges in the past year in order to decipher mechanisms of host responses and interpret disease pathogenesis. Comparatively little is known in regard to how the immune response against SARS-CoV-2 differs from other respiratory infections. In our study, we compare the peripheral blood immune signature from SARS-CoV-2 infected patients to patients hospitalized pre-pandemic with Influenza Virus or Respiratory Syncytial Virus (RSV). Our in-depth profiling indicates that the immune landscape in patients infected by SARS-CoV-2 is largely similar to patients hospitalized with Flu or RSV. Similarly, serum cytokine and chemokine expression patterns were largely overlapping. Unique to patients infected with SARS-CoV-2 who had the most critical clinical disease state were changes in the regulatory T cell (Treg) compartment. A Treg signature including increased frequency, activation status, and migration markers was correlated with the severity of COVID-19 disease. These findings are particularly relevant as Tregs are being discussed as a therapy to combat the severe inflammation seen in COVID-19 patients. Likewise, having defined the overlapping immune landscapes in SARS-CoV-2, existing knowledge of Flu and RSV infections could be leveraged to identify common treatment strategies. Cold Spring Harbor Laboratory 2021-03-26 /pmc/articles/PMC8010752/ /pubmed/33791720 http://dx.doi.org/10.1101/2021.03.25.21254376 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Vick, Sarah C. Frutoso, Marie Mair, Florian Konecny, Andrew J. Greene, Evan Wolf, Caitlin R. Logue, Jennifer K. Boonyaratanakornkit, Jim Gottardo, Raphael Schiffer, Joshua T. Chu, Helen Y. Prlic, Martin Lund, Jennifer M. A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections |
title | A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections |
title_full | A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections |
title_fullStr | A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections |
title_full_unstemmed | A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections |
title_short | A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections |
title_sort | differential regulatory t cell signature distinguishes the immune landscape of covid-19 hospitalized patients from those hospitalized with other respiratory viral infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010752/ https://www.ncbi.nlm.nih.gov/pubmed/33791720 http://dx.doi.org/10.1101/2021.03.25.21254376 |
work_keys_str_mv | AT vicksarahc adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT frutosomarie adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT mairflorian adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT konecnyandrewj adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT greeneevan adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT wolfcaitlinr adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT loguejenniferk adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT boonyaratanakornkitjim adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT gottardoraphael adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT schifferjoshuat adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT chuheleny adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT prlicmartin adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT lundjenniferm adifferentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT vicksarahc differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT frutosomarie differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT mairflorian differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT konecnyandrewj differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT greeneevan differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT wolfcaitlinr differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT loguejenniferk differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT boonyaratanakornkitjim differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT gottardoraphael differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT schifferjoshuat differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT chuheleny differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT prlicmartin differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections AT lundjenniferm differentialregulatorytcellsignaturedistinguishestheimmunelandscapeofcovid19hospitalizedpatientsfromthosehospitalizedwithotherrespiratoryviralinfections |