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A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections

SARS-CoV-2 infection has caused a lasting global pandemic costing millions of lives and untold additional costs. Understanding the immune response to SARS-CoV-2 has been one of the main challenges in the past year in order to decipher mechanisms of host responses and interpret disease pathogenesis....

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Autores principales: Vick, Sarah C., Frutoso, Marie, Mair, Florian, Konecny, Andrew J., Greene, Evan, Wolf, Caitlin R., Logue, Jennifer K., Boonyaratanakornkit, Jim, Gottardo, Raphael, Schiffer, Joshua T., Chu, Helen Y., Prlic, Martin, Lund, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010752/
https://www.ncbi.nlm.nih.gov/pubmed/33791720
http://dx.doi.org/10.1101/2021.03.25.21254376
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author Vick, Sarah C.
Frutoso, Marie
Mair, Florian
Konecny, Andrew J.
Greene, Evan
Wolf, Caitlin R.
Logue, Jennifer K.
Boonyaratanakornkit, Jim
Gottardo, Raphael
Schiffer, Joshua T.
Chu, Helen Y.
Prlic, Martin
Lund, Jennifer M.
author_facet Vick, Sarah C.
Frutoso, Marie
Mair, Florian
Konecny, Andrew J.
Greene, Evan
Wolf, Caitlin R.
Logue, Jennifer K.
Boonyaratanakornkit, Jim
Gottardo, Raphael
Schiffer, Joshua T.
Chu, Helen Y.
Prlic, Martin
Lund, Jennifer M.
author_sort Vick, Sarah C.
collection PubMed
description SARS-CoV-2 infection has caused a lasting global pandemic costing millions of lives and untold additional costs. Understanding the immune response to SARS-CoV-2 has been one of the main challenges in the past year in order to decipher mechanisms of host responses and interpret disease pathogenesis. Comparatively little is known in regard to how the immune response against SARS-CoV-2 differs from other respiratory infections. In our study, we compare the peripheral blood immune signature from SARS-CoV-2 infected patients to patients hospitalized pre-pandemic with Influenza Virus or Respiratory Syncytial Virus (RSV). Our in-depth profiling indicates that the immune landscape in patients infected by SARS-CoV-2 is largely similar to patients hospitalized with Flu or RSV. Similarly, serum cytokine and chemokine expression patterns were largely overlapping. Unique to patients infected with SARS-CoV-2 who had the most critical clinical disease state were changes in the regulatory T cell (Treg) compartment. A Treg signature including increased frequency, activation status, and migration markers was correlated with the severity of COVID-19 disease. These findings are particularly relevant as Tregs are being discussed as a therapy to combat the severe inflammation seen in COVID-19 patients. Likewise, having defined the overlapping immune landscapes in SARS-CoV-2, existing knowledge of Flu and RSV infections could be leveraged to identify common treatment strategies.
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spelling pubmed-80107522021-04-01 A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections Vick, Sarah C. Frutoso, Marie Mair, Florian Konecny, Andrew J. Greene, Evan Wolf, Caitlin R. Logue, Jennifer K. Boonyaratanakornkit, Jim Gottardo, Raphael Schiffer, Joshua T. Chu, Helen Y. Prlic, Martin Lund, Jennifer M. medRxiv Article SARS-CoV-2 infection has caused a lasting global pandemic costing millions of lives and untold additional costs. Understanding the immune response to SARS-CoV-2 has been one of the main challenges in the past year in order to decipher mechanisms of host responses and interpret disease pathogenesis. Comparatively little is known in regard to how the immune response against SARS-CoV-2 differs from other respiratory infections. In our study, we compare the peripheral blood immune signature from SARS-CoV-2 infected patients to patients hospitalized pre-pandemic with Influenza Virus or Respiratory Syncytial Virus (RSV). Our in-depth profiling indicates that the immune landscape in patients infected by SARS-CoV-2 is largely similar to patients hospitalized with Flu or RSV. Similarly, serum cytokine and chemokine expression patterns were largely overlapping. Unique to patients infected with SARS-CoV-2 who had the most critical clinical disease state were changes in the regulatory T cell (Treg) compartment. A Treg signature including increased frequency, activation status, and migration markers was correlated with the severity of COVID-19 disease. These findings are particularly relevant as Tregs are being discussed as a therapy to combat the severe inflammation seen in COVID-19 patients. Likewise, having defined the overlapping immune landscapes in SARS-CoV-2, existing knowledge of Flu and RSV infections could be leveraged to identify common treatment strategies. Cold Spring Harbor Laboratory 2021-03-26 /pmc/articles/PMC8010752/ /pubmed/33791720 http://dx.doi.org/10.1101/2021.03.25.21254376 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Vick, Sarah C.
Frutoso, Marie
Mair, Florian
Konecny, Andrew J.
Greene, Evan
Wolf, Caitlin R.
Logue, Jennifer K.
Boonyaratanakornkit, Jim
Gottardo, Raphael
Schiffer, Joshua T.
Chu, Helen Y.
Prlic, Martin
Lund, Jennifer M.
A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
title A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
title_full A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
title_fullStr A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
title_full_unstemmed A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
title_short A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
title_sort differential regulatory t cell signature distinguishes the immune landscape of covid-19 hospitalized patients from those hospitalized with other respiratory viral infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010752/
https://www.ncbi.nlm.nih.gov/pubmed/33791720
http://dx.doi.org/10.1101/2021.03.25.21254376
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