Accelerated RNA detection using tandem CRISPR nucleases

Direct, amplification-free detection of RNA has the potential to transform molecular diagnostics by enabling simple on-site analysis of human or environmental samples. CRISPR-Cas nucleases offer programmable RNA-guided recognition of RNA that triggers cleavage and release of a fluorescent reporter m...

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Detalles Bibliográficos
Autores principales: Liu, Tina Y., Knott, Gavin J., Smock, Dylan C. J., Desmarais, John J., Son, Sungmin, Bhuiya, Abdul, Jakhanwal, Shrutee, Prywes, Noam, Agrawal, Shreeya, de León Derby, María Díaz, Switz, Neil A., Armstrong, Maxim, Harris, Andrew R., Charles, Emeric J., Thornton, Brittney W., Fozouni, Parinaz, Shu, Jeffrey, Stephens, Stephanie I., Kumar, G. Renuka, Zhao, Chunyu, Mok, Amanda, Iavarone, Anthony T., Escajeda, Arturo M., McIntosh, Roger, Kim, Shin E., Dugan, Eli J., Pollard, Katherine S., Tan, Ming X., Ott, Melanie, Fletcher, Daniel A., Lareau, Liana F., Hsu, Patrick D., Savage, David F., Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010768/
https://www.ncbi.nlm.nih.gov/pubmed/33791736
http://dx.doi.org/10.1101/2021.03.19.21253328

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