Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms

Long noncoding RNAs (lncRNAs) are noncoding RNAs longer than 200 nt that have almost no function for encoding proteins. As an important regulatory molecule of the human genome, lncRNAs play a regulatory role in the human body. LncRNAs have a variety of functions, such as signaling, guiding, baiting...

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Detalles Bibliográficos
Autores principales: Tan, Bibo, Li, Fang, Chen, Zihao, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010804/
https://www.ncbi.nlm.nih.gov/pubmed/33769145
http://dx.doi.org/10.1177/15330338211004940
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author Tan, Bibo
Li, Fang
Chen, Zihao
Li, Yong
author_facet Tan, Bibo
Li, Fang
Chen, Zihao
Li, Yong
author_sort Tan, Bibo
collection PubMed
description Long noncoding RNAs (lncRNAs) are noncoding RNAs longer than 200 nt that have almost no function for encoding proteins. As an important regulatory molecule of the human genome, lncRNAs play a regulatory role in the human body. LncRNAs have a variety of functions, such as signaling, guiding, baiting or scaffolding of functional proteins, and are closely related to tumor development. Gastric cancer is one of the most common malignant tumors. It has a high incidence, a low early diagnosis rate, and a poor prognosis, and it seriously threatens human health. Abnormal expression of lncRNAs can affect the occurrence, development, invasion and metastasis of gastric cancer. Therefore, lncRNAs are expected to become important biomarkers and new targets for the diagnosis and treatment of gastric cancer. LncRNAs have a significant potential to guide the diagnosis, treatment and prognosis of gastric cancer. This article reviews lncRNAs and the mechanisms that have been discovered in recent years related to gastrointestinal tumors.
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spelling pubmed-80108042021-04-13 Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms Tan, Bibo Li, Fang Chen, Zihao Li, Yong Technol Cancer Res Treat Review Long noncoding RNAs (lncRNAs) are noncoding RNAs longer than 200 nt that have almost no function for encoding proteins. As an important regulatory molecule of the human genome, lncRNAs play a regulatory role in the human body. LncRNAs have a variety of functions, such as signaling, guiding, baiting or scaffolding of functional proteins, and are closely related to tumor development. Gastric cancer is one of the most common malignant tumors. It has a high incidence, a low early diagnosis rate, and a poor prognosis, and it seriously threatens human health. Abnormal expression of lncRNAs can affect the occurrence, development, invasion and metastasis of gastric cancer. Therefore, lncRNAs are expected to become important biomarkers and new targets for the diagnosis and treatment of gastric cancer. LncRNAs have a significant potential to guide the diagnosis, treatment and prognosis of gastric cancer. This article reviews lncRNAs and the mechanisms that have been discovered in recent years related to gastrointestinal tumors. SAGE Publications 2021-03-26 /pmc/articles/PMC8010804/ /pubmed/33769145 http://dx.doi.org/10.1177/15330338211004940 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Tan, Bibo
Li, Fang
Chen, Zihao
Li, Yong
Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
title Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
title_full Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
title_fullStr Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
title_full_unstemmed Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
title_short Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
title_sort research progress and application prospects of long noncoding rnas in gastric neoplasms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010804/
https://www.ncbi.nlm.nih.gov/pubmed/33769145
http://dx.doi.org/10.1177/15330338211004940
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