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Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice

Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice with alloxan-induced diabetes were recently reported. The present work was aimed at studying the efficiency of thymulin and PRDX6 in a type 1 diabetes mellitus model induced by streptozotocin in mice. Effects of...

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Autores principales: Novoselova, Elena G, Glushkova, Olga V, Lunin, Sergey M, Khrenov, Maxim O, Parfenyuk, Svetlana B, Novoselova, Tatyana V, Sharapov, Mars G, Gordeeva, Alina E, Novoselov, Vladimir I, Fesenko, Evgeny E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010817/
https://www.ncbi.nlm.nih.gov/pubmed/33779346
http://dx.doi.org/10.1177/20587384211005645
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author Novoselova, Elena G
Glushkova, Olga V
Lunin, Sergey M
Khrenov, Maxim O
Parfenyuk, Svetlana B
Novoselova, Tatyana V
Sharapov, Mars G
Gordeeva, Alina E
Novoselov, Vladimir I
Fesenko, Evgeny E
author_facet Novoselova, Elena G
Glushkova, Olga V
Lunin, Sergey M
Khrenov, Maxim O
Parfenyuk, Svetlana B
Novoselova, Tatyana V
Sharapov, Mars G
Gordeeva, Alina E
Novoselov, Vladimir I
Fesenko, Evgeny E
author_sort Novoselova, Elena G
collection PubMed
description Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice with alloxan-induced diabetes were recently reported. The present work was aimed at studying the efficiency of thymulin and PRDX6 in a type 1 diabetes mellitus model induced by streptozotocin in mice. Effects of prolonged treatment with PRDX6 or thymic peptide thymulin on diabetes development were evaluated. We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-α, interleukin-5 and 17, and interferon-γ), activity of NF-κB and JNK pathways, and Hsp90α expression in immune cells. Both thymulin and PRDX6 reduced the physiological impairments in diabetic mice at various levels. Thymulin and PRDX6 provide beneficial effects in the model of diabetes via very different mechanisms. Taken together, the results of our study indicated that the thymic peptide and the antioxidant enzyme have anti-inflammatory functions. As increasing evidences show diabetes mellitus as a distinct comorbidity leading to acute respiratory distress syndrome and increased mortality in patients with COVID-19 having cytokine storm, thymulin, and PRDX6 might serve as a supporting anti-inflammatory treatment in the therapy of COVID 19 in diabetic patients.
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spelling pubmed-80108172021-04-13 Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice Novoselova, Elena G Glushkova, Olga V Lunin, Sergey M Khrenov, Maxim O Parfenyuk, Svetlana B Novoselova, Tatyana V Sharapov, Mars G Gordeeva, Alina E Novoselov, Vladimir I Fesenko, Evgeny E Int J Immunopathol Pharmacol Original Research Article Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice with alloxan-induced diabetes were recently reported. The present work was aimed at studying the efficiency of thymulin and PRDX6 in a type 1 diabetes mellitus model induced by streptozotocin in mice. Effects of prolonged treatment with PRDX6 or thymic peptide thymulin on diabetes development were evaluated. We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-α, interleukin-5 and 17, and interferon-γ), activity of NF-κB and JNK pathways, and Hsp90α expression in immune cells. Both thymulin and PRDX6 reduced the physiological impairments in diabetic mice at various levels. Thymulin and PRDX6 provide beneficial effects in the model of diabetes via very different mechanisms. Taken together, the results of our study indicated that the thymic peptide and the antioxidant enzyme have anti-inflammatory functions. As increasing evidences show diabetes mellitus as a distinct comorbidity leading to acute respiratory distress syndrome and increased mortality in patients with COVID-19 having cytokine storm, thymulin, and PRDX6 might serve as a supporting anti-inflammatory treatment in the therapy of COVID 19 in diabetic patients. SAGE Publications 2021-03-28 /pmc/articles/PMC8010817/ /pubmed/33779346 http://dx.doi.org/10.1177/20587384211005645 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Novoselova, Elena G
Glushkova, Olga V
Lunin, Sergey M
Khrenov, Maxim O
Parfenyuk, Svetlana B
Novoselova, Tatyana V
Sharapov, Mars G
Gordeeva, Alina E
Novoselov, Vladimir I
Fesenko, Evgeny E
Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
title Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
title_full Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
title_fullStr Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
title_full_unstemmed Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
title_short Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
title_sort thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010817/
https://www.ncbi.nlm.nih.gov/pubmed/33779346
http://dx.doi.org/10.1177/20587384211005645
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