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Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice
Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice with alloxan-induced diabetes were recently reported. The present work was aimed at studying the efficiency of thymulin and PRDX6 in a type 1 diabetes mellitus model induced by streptozotocin in mice. Effects of...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010817/ https://www.ncbi.nlm.nih.gov/pubmed/33779346 http://dx.doi.org/10.1177/20587384211005645 |
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author | Novoselova, Elena G Glushkova, Olga V Lunin, Sergey M Khrenov, Maxim O Parfenyuk, Svetlana B Novoselova, Tatyana V Sharapov, Mars G Gordeeva, Alina E Novoselov, Vladimir I Fesenko, Evgeny E |
author_facet | Novoselova, Elena G Glushkova, Olga V Lunin, Sergey M Khrenov, Maxim O Parfenyuk, Svetlana B Novoselova, Tatyana V Sharapov, Mars G Gordeeva, Alina E Novoselov, Vladimir I Fesenko, Evgeny E |
author_sort | Novoselova, Elena G |
collection | PubMed |
description | Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice with alloxan-induced diabetes were recently reported. The present work was aimed at studying the efficiency of thymulin and PRDX6 in a type 1 diabetes mellitus model induced by streptozotocin in mice. Effects of prolonged treatment with PRDX6 or thymic peptide thymulin on diabetes development were evaluated. We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-α, interleukin-5 and 17, and interferon-γ), activity of NF-κB and JNK pathways, and Hsp90α expression in immune cells. Both thymulin and PRDX6 reduced the physiological impairments in diabetic mice at various levels. Thymulin and PRDX6 provide beneficial effects in the model of diabetes via very different mechanisms. Taken together, the results of our study indicated that the thymic peptide and the antioxidant enzyme have anti-inflammatory functions. As increasing evidences show diabetes mellitus as a distinct comorbidity leading to acute respiratory distress syndrome and increased mortality in patients with COVID-19 having cytokine storm, thymulin, and PRDX6 might serve as a supporting anti-inflammatory treatment in the therapy of COVID 19 in diabetic patients. |
format | Online Article Text |
id | pubmed-8010817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-80108172021-04-13 Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice Novoselova, Elena G Glushkova, Olga V Lunin, Sergey M Khrenov, Maxim O Parfenyuk, Svetlana B Novoselova, Tatyana V Sharapov, Mars G Gordeeva, Alina E Novoselov, Vladimir I Fesenko, Evgeny E Int J Immunopathol Pharmacol Original Research Article Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice with alloxan-induced diabetes were recently reported. The present work was aimed at studying the efficiency of thymulin and PRDX6 in a type 1 diabetes mellitus model induced by streptozotocin in mice. Effects of prolonged treatment with PRDX6 or thymic peptide thymulin on diabetes development were evaluated. We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-α, interleukin-5 and 17, and interferon-γ), activity of NF-κB and JNK pathways, and Hsp90α expression in immune cells. Both thymulin and PRDX6 reduced the physiological impairments in diabetic mice at various levels. Thymulin and PRDX6 provide beneficial effects in the model of diabetes via very different mechanisms. Taken together, the results of our study indicated that the thymic peptide and the antioxidant enzyme have anti-inflammatory functions. As increasing evidences show diabetes mellitus as a distinct comorbidity leading to acute respiratory distress syndrome and increased mortality in patients with COVID-19 having cytokine storm, thymulin, and PRDX6 might serve as a supporting anti-inflammatory treatment in the therapy of COVID 19 in diabetic patients. SAGE Publications 2021-03-28 /pmc/articles/PMC8010817/ /pubmed/33779346 http://dx.doi.org/10.1177/20587384211005645 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Novoselova, Elena G Glushkova, Olga V Lunin, Sergey M Khrenov, Maxim O Parfenyuk, Svetlana B Novoselova, Tatyana V Sharapov, Mars G Gordeeva, Alina E Novoselov, Vladimir I Fesenko, Evgeny E Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice |
title | Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice |
title_full | Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice |
title_fullStr | Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice |
title_full_unstemmed | Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice |
title_short | Thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice |
title_sort | thymulin and peroxiredoxin 6 have protective effects against streptozotocin-induced type 1 diabetes in mice |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010817/ https://www.ncbi.nlm.nih.gov/pubmed/33779346 http://dx.doi.org/10.1177/20587384211005645 |
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