MTSplice predicts effects of genetic variants on tissue-specific splicing

We develop the free and open-source model Multi-tissue Splicing (MTSplice) to predict the effects of genetic variants on splicing of cassette exons in 56 human tissues. MTSplice combines MMSplice, which models constitutive regulatory sequences, with a new neural network that models tissue-specific r...

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Detalles Bibliográficos
Autores principales: Cheng, Jun, Çelik, Muhammed Hasan, Kundaje, Anshul, Gagneur, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011109/
https://www.ncbi.nlm.nih.gov/pubmed/33789710
http://dx.doi.org/10.1186/s13059-021-02273-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011109/
https://www.ncbi.nlm.nih.gov/pubmed/33789710
http://dx.doi.org/10.1186/s13059-021-02273-7

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