Autoantibodies to speckled protein family in primary biliary cholangitis

The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “mult...

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Autores principales: Granito, Alessandro, Muratori, Luigi, Tovoli, Francesco, Muratori, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011120/
https://www.ncbi.nlm.nih.gov/pubmed/33789734
http://dx.doi.org/10.1186/s13223-021-00539-0
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author Granito, Alessandro
Muratori, Luigi
Tovoli, Francesco
Muratori, Paolo
author_facet Granito, Alessandro
Muratori, Luigi
Tovoli, Francesco
Muratori, Paolo
author_sort Granito, Alessandro
collection PubMed
description The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.
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spelling pubmed-80111202021-03-31 Autoantibodies to speckled protein family in primary biliary cholangitis Granito, Alessandro Muratori, Luigi Tovoli, Francesco Muratori, Paolo Allergy Asthma Clin Immunol Letter to the Editor The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches. BioMed Central 2021-03-31 /pmc/articles/PMC8011120/ /pubmed/33789734 http://dx.doi.org/10.1186/s13223-021-00539-0 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Granito, Alessandro
Muratori, Luigi
Tovoli, Francesco
Muratori, Paolo
Autoantibodies to speckled protein family in primary biliary cholangitis
title Autoantibodies to speckled protein family in primary biliary cholangitis
title_full Autoantibodies to speckled protein family in primary biliary cholangitis
title_fullStr Autoantibodies to speckled protein family in primary biliary cholangitis
title_full_unstemmed Autoantibodies to speckled protein family in primary biliary cholangitis
title_short Autoantibodies to speckled protein family in primary biliary cholangitis
title_sort autoantibodies to speckled protein family in primary biliary cholangitis
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011120/
https://www.ncbi.nlm.nih.gov/pubmed/33789734
http://dx.doi.org/10.1186/s13223-021-00539-0
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