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Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review

BACKGROUND: Caffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the perioperative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the...

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Autores principales: Bright, M., Raman, V., Laupland, K. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011218/
https://www.ncbi.nlm.nih.gov/pubmed/33789583
http://dx.doi.org/10.1186/s12871-021-01320-x
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author Bright, M.
Raman, V.
Laupland, K. B.
author_facet Bright, M.
Raman, V.
Laupland, K. B.
author_sort Bright, M.
collection PubMed
description BACKGROUND: Caffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the perioperative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the intensive care unit (ICU) and postoperative patients. METHODS: PubMed, Embase, CINAHL Complete, Scopus and Web of Science were systematically searched for studies investigating the effects of caffeine withdrawal or administration in ICU patients and in the perioperative period. Areas of recent systematic review such as pain or post-dural puncture headache were not included in this review. Studies were limited to adults. RESULTS: Of 2268 articles screened, 26 were included and grouped into two themes of caffeine use in in the perioperative period and in the ICU. Caffeine withdrawal in the postoperative period increases the incidence of headache, which can be effectively treated prophylactically with perioperative caffeine. There were no studies investigating caffeine withdrawal or effect on sleep wake cycles, daytime somnolence, or delirium in the intensive care setting. Administration of caffeine results in faster emergence from sedation and anaesthesia, particularly in individuals who are at high risk of post-extubation complications. There has only been one study investigating caffeine administration to facilitate post-anaesthetic emergence in ICU. Caffeine administration appears to be safe in moderate doses in the perioperative period and in the intensive care setting. CONCLUSIONS: Although caffeine is widely used, there is a paucity of studies investigating withdrawal or therapeutic effects in patients admitted to ICU and further novel studies are a priority. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12871-021-01320-x.
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spelling pubmed-80112182021-04-01 Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review Bright, M. Raman, V. Laupland, K. B. BMC Anesthesiol Research Article BACKGROUND: Caffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the perioperative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the intensive care unit (ICU) and postoperative patients. METHODS: PubMed, Embase, CINAHL Complete, Scopus and Web of Science were systematically searched for studies investigating the effects of caffeine withdrawal or administration in ICU patients and in the perioperative period. Areas of recent systematic review such as pain or post-dural puncture headache were not included in this review. Studies were limited to adults. RESULTS: Of 2268 articles screened, 26 were included and grouped into two themes of caffeine use in in the perioperative period and in the ICU. Caffeine withdrawal in the postoperative period increases the incidence of headache, which can be effectively treated prophylactically with perioperative caffeine. There were no studies investigating caffeine withdrawal or effect on sleep wake cycles, daytime somnolence, or delirium in the intensive care setting. Administration of caffeine results in faster emergence from sedation and anaesthesia, particularly in individuals who are at high risk of post-extubation complications. There has only been one study investigating caffeine administration to facilitate post-anaesthetic emergence in ICU. Caffeine administration appears to be safe in moderate doses in the perioperative period and in the intensive care setting. CONCLUSIONS: Although caffeine is widely used, there is a paucity of studies investigating withdrawal or therapeutic effects in patients admitted to ICU and further novel studies are a priority. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12871-021-01320-x. BioMed Central 2021-03-31 /pmc/articles/PMC8011218/ /pubmed/33789583 http://dx.doi.org/10.1186/s12871-021-01320-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Bright, M.
Raman, V.
Laupland, K. B.
Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review
title Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review
title_full Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review
title_fullStr Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review
title_full_unstemmed Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review
title_short Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review
title_sort use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011218/
https://www.ncbi.nlm.nih.gov/pubmed/33789583
http://dx.doi.org/10.1186/s12871-021-01320-x
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