Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice

Frameshifts in the Calreticulin (CALR) exon 9 provide a recurrent driver mutation of essential thrombocythemia (ET) and primary myelofibrosis among myeloproliferative neoplasms (MPNs). Here, we generated knock-in mice with murine Calr exon 9 mimicking the human CALR mutations, using the CRISPR-Cas9...

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Detalles Bibliográficos
Autores principales: Minakawa, Keiji, Yokokawa, Tetsuro, Ueda, Koki, Nakajima, Osamu, Misaka, Tomofumi, Kimishima, Yusuke, Wada, Kento, Tomita, Yusuke, Miura, Saori, Sato, Yuka, Mimura, Kosaku, Sugimoto, Koichi, Nakazato, Kazuhiko, Nollet, Kenneth E., Ogawa, Kazuei, Ikezoe, Takayuki, Hashimoto, Yuko, Takeishi, Yasuchika, Ikeda, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011226/
https://www.ncbi.nlm.nih.gov/pubmed/33785036
http://dx.doi.org/10.1186/s13045-021-01064-8

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