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IL-1R2 expression in human gastric cancer and its clinical significance

Background: Interleukin-1 receptor type II (IL-1R2), also known as CD121b, is a member of the IL-1 receptor family. IL-1R2 acts as negative regulator of the IL-1 system, modulating IL-1 availability for the signaling receptor. IL-1R2 is abnormally expressed in many human inflammatory diseases and ca...

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Autores principales: Yuan, Maoling, Wang, Lei, Huang, Hao, Li, Yuan, Zheng, Xiao, Shao, Qi, Jiang, Jingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011276/
https://www.ncbi.nlm.nih.gov/pubmed/33704402
http://dx.doi.org/10.1042/BSR20204425
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author Yuan, Maoling
Wang, Lei
Huang, Hao
Li, Yuan
Zheng, Xiao
Shao, Qi
Jiang, Jingting
author_facet Yuan, Maoling
Wang, Lei
Huang, Hao
Li, Yuan
Zheng, Xiao
Shao, Qi
Jiang, Jingting
author_sort Yuan, Maoling
collection PubMed
description Background: Interleukin-1 receptor type II (IL-1R2), also known as CD121b, is a member of the IL-1 receptor family. IL-1R2 acts as negative regulator of the IL-1 system, modulating IL-1 availability for the signaling receptor. IL-1R2 is abnormally expressed in many human inflammatory diseases and cancers, and has important clinical significance. The present study was designed to investigate IL-1R2 expression in human gastric cancer (GC) tissues and the associated clinical implications. Methods: Immunohistochemistry was used to identify the clinical significance and prognostic value of IL-1R2 expression in GC tissues. We investigated IL-1R2 expression in GC tissues, cells, and serum using real-time PCR (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) assays. Results: IL-1R2 was highly expressed in GC tissues, and the overall survival in patients with advanced GC and high IL-1R2 expression was significantly poorer than that in patients with advanced GC and low IL-1R2 expression. Moreover, IL-1R2 mRNA levels in GC tissues and most GC cells were higher than those in para-cancer tissues and GES1 human gastric mucosal epithelial cells. The level of plasma-soluble IL-1R2 in GC patients was higher than that of the healthy control group. Conclusion: Increased IL-1R2 levels are involved in the initiation and progression of human GC, and IL-1R2 might be employed to develop immunotherapeutic approaches targeting GC.
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spelling pubmed-80112762021-04-08 IL-1R2 expression in human gastric cancer and its clinical significance Yuan, Maoling Wang, Lei Huang, Hao Li, Yuan Zheng, Xiao Shao, Qi Jiang, Jingting Biosci Rep Cancer Background: Interleukin-1 receptor type II (IL-1R2), also known as CD121b, is a member of the IL-1 receptor family. IL-1R2 acts as negative regulator of the IL-1 system, modulating IL-1 availability for the signaling receptor. IL-1R2 is abnormally expressed in many human inflammatory diseases and cancers, and has important clinical significance. The present study was designed to investigate IL-1R2 expression in human gastric cancer (GC) tissues and the associated clinical implications. Methods: Immunohistochemistry was used to identify the clinical significance and prognostic value of IL-1R2 expression in GC tissues. We investigated IL-1R2 expression in GC tissues, cells, and serum using real-time PCR (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) assays. Results: IL-1R2 was highly expressed in GC tissues, and the overall survival in patients with advanced GC and high IL-1R2 expression was significantly poorer than that in patients with advanced GC and low IL-1R2 expression. Moreover, IL-1R2 mRNA levels in GC tissues and most GC cells were higher than those in para-cancer tissues and GES1 human gastric mucosal epithelial cells. The level of plasma-soluble IL-1R2 in GC patients was higher than that of the healthy control group. Conclusion: Increased IL-1R2 levels are involved in the initiation and progression of human GC, and IL-1R2 might be employed to develop immunotherapeutic approaches targeting GC. Portland Press Ltd. 2021-03-26 /pmc/articles/PMC8011276/ /pubmed/33704402 http://dx.doi.org/10.1042/BSR20204425 Text en © 2021 The Author(s). http://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cancer
Yuan, Maoling
Wang, Lei
Huang, Hao
Li, Yuan
Zheng, Xiao
Shao, Qi
Jiang, Jingting
IL-1R2 expression in human gastric cancer and its clinical significance
title IL-1R2 expression in human gastric cancer and its clinical significance
title_full IL-1R2 expression in human gastric cancer and its clinical significance
title_fullStr IL-1R2 expression in human gastric cancer and its clinical significance
title_full_unstemmed IL-1R2 expression in human gastric cancer and its clinical significance
title_short IL-1R2 expression in human gastric cancer and its clinical significance
title_sort il-1r2 expression in human gastric cancer and its clinical significance
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011276/
https://www.ncbi.nlm.nih.gov/pubmed/33704402
http://dx.doi.org/10.1042/BSR20204425
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