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Warburg-like Metabolic Reprogramming in Aging Intestinal Stem Cells Contributes to Tissue Hyperplasia

In many tissues, stem cell (SC) proliferation is dynamically adjusted to regenerative needs. How SCs adapt their metabolism to meet the demands of proliferation and how changes in such adaptive mechanisms contribute to age-related dysfunction remain poorly understood. Here, we identify mitochondrial...

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Detalles Bibliográficos
Autores principales: Morris, Otto, Deng, Hansong, Tam, Christine, Jasper, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011352/
https://www.ncbi.nlm.nih.gov/pubmed/33238124
http://dx.doi.org/10.1016/j.celrep.2020.108423