Optogenetic activation of spinal microglia triggers chronic pain in mice

Spinal microglia are highly responsive to peripheral nerve injury and are known to be a key player in pain. However, there has not been direct evidence showing that selective microglial activation in vivo is sufficient to induce chronic pain. Here, we used optogenetic approaches in microglia to addr...

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Detalles Bibliográficos
Autores principales: Yi, Min-Hee, Liu, Yong U., Umpierre, Anthony D., Chen, Tingjun, Ying, Yanlu, Zheng, Jiaying, Dheer, Aastha, Bosco, Dale B., Dong, Hailong, Wu, Long-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011727/
https://www.ncbi.nlm.nih.gov/pubmed/33739978
http://dx.doi.org/10.1371/journal.pbio.3001154

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