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Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review

A systematic chart review was performed to estimate the frequency of pregnancy outcomes, pregnancy complications and neonatal outcomes at facilities in Blantyre, Malawi; Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza and Harare, Zimbabwe to provide comparisons with estimates from an on...

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Autores principales: Balkus, Jennifer E., Neradilek, Moni, Fairlie, Lee, Makanani, Bonus, Mgodi, Nyaradzo, Mhlanga, Felix, Nakabiito, Clemensia, Mayo, Ashley, Harrell, Tanya, Piper, Jeanna, Bunge, Katherine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011748/
https://www.ncbi.nlm.nih.gov/pubmed/33788867
http://dx.doi.org/10.1371/journal.pone.0248423
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author Balkus, Jennifer E.
Neradilek, Moni
Fairlie, Lee
Makanani, Bonus
Mgodi, Nyaradzo
Mhlanga, Felix
Nakabiito, Clemensia
Mayo, Ashley
Harrell, Tanya
Piper, Jeanna
Bunge, Katherine E.
author_facet Balkus, Jennifer E.
Neradilek, Moni
Fairlie, Lee
Makanani, Bonus
Mgodi, Nyaradzo
Mhlanga, Felix
Nakabiito, Clemensia
Mayo, Ashley
Harrell, Tanya
Piper, Jeanna
Bunge, Katherine E.
author_sort Balkus, Jennifer E.
collection PubMed
description A systematic chart review was performed to estimate the frequency of pregnancy outcomes, pregnancy complications and neonatal outcomes at facilities in Blantyre, Malawi; Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza and Harare, Zimbabwe to provide comparisons with estimates from an ongoing clinical trial evaluating the safety of two biomedical HIV prevention interventions in pregnancy. A multi-site, cross-sectional chart review was conducted at Maternal Obstetric Units and hospitals where women participating in the ongoing clinical trial would be expected to deliver. All individuals delivering at the designated facilities or admitted for postpartum care within seven days of a delivery elsewhere (home, health clinic, etc.) were included in the review. Data were abstracted for pregnancy outcomes, pregnancy complications, maternal and neonatal death, and congenital anomalies. Data from 10,138 records were abstracted across all four sites (Blantyre n = 2,384; Johannesburg n = 1,888; Kampala n = 3,708; Chitungwiza and Harare n = 2,158), which included 10,426 pregnancy outcomes. The prevalence of preterm birth was 13% (range across sites: 10.4–20.7) and 4.1% of deliveries resulted in stillbirth (range: 3.1–5.5). The most commonly noted pregnancy complication was gestational hypertension, reported among 4.4% of pregnancies. Among pregnancies resulting in a live birth, 15.5% were low birthweight (range: 13.8–17.4) and 2.0% resulted in neonatal death (range:1.2–3.2). Suspected congenital anomalies were noted in 1.2% of pregnancies. This study provides systematically collected data on background rates of pregnancy outcomes, pregnancy complications and neonatal outcomes that can be used as a reference in support of ongoing HIV prevention studies. In addition, estimates from this study provide important background data for future studies of investigational products evaluated in pregnancy in these urban settings.
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spelling pubmed-80117482021-04-07 Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review Balkus, Jennifer E. Neradilek, Moni Fairlie, Lee Makanani, Bonus Mgodi, Nyaradzo Mhlanga, Felix Nakabiito, Clemensia Mayo, Ashley Harrell, Tanya Piper, Jeanna Bunge, Katherine E. PLoS One Research Article A systematic chart review was performed to estimate the frequency of pregnancy outcomes, pregnancy complications and neonatal outcomes at facilities in Blantyre, Malawi; Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza and Harare, Zimbabwe to provide comparisons with estimates from an ongoing clinical trial evaluating the safety of two biomedical HIV prevention interventions in pregnancy. A multi-site, cross-sectional chart review was conducted at Maternal Obstetric Units and hospitals where women participating in the ongoing clinical trial would be expected to deliver. All individuals delivering at the designated facilities or admitted for postpartum care within seven days of a delivery elsewhere (home, health clinic, etc.) were included in the review. Data were abstracted for pregnancy outcomes, pregnancy complications, maternal and neonatal death, and congenital anomalies. Data from 10,138 records were abstracted across all four sites (Blantyre n = 2,384; Johannesburg n = 1,888; Kampala n = 3,708; Chitungwiza and Harare n = 2,158), which included 10,426 pregnancy outcomes. The prevalence of preterm birth was 13% (range across sites: 10.4–20.7) and 4.1% of deliveries resulted in stillbirth (range: 3.1–5.5). The most commonly noted pregnancy complication was gestational hypertension, reported among 4.4% of pregnancies. Among pregnancies resulting in a live birth, 15.5% were low birthweight (range: 13.8–17.4) and 2.0% resulted in neonatal death (range:1.2–3.2). Suspected congenital anomalies were noted in 1.2% of pregnancies. This study provides systematically collected data on background rates of pregnancy outcomes, pregnancy complications and neonatal outcomes that can be used as a reference in support of ongoing HIV prevention studies. In addition, estimates from this study provide important background data for future studies of investigational products evaluated in pregnancy in these urban settings. Public Library of Science 2021-03-31 /pmc/articles/PMC8011748/ /pubmed/33788867 http://dx.doi.org/10.1371/journal.pone.0248423 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Balkus, Jennifer E.
Neradilek, Moni
Fairlie, Lee
Makanani, Bonus
Mgodi, Nyaradzo
Mhlanga, Felix
Nakabiito, Clemensia
Mayo, Ashley
Harrell, Tanya
Piper, Jeanna
Bunge, Katherine E.
Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review
title Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review
title_full Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review
title_fullStr Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review
title_full_unstemmed Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review
title_short Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review
title_sort assessing pregnancy and neonatal outcomes in malawi, south africa, uganda, and zimbabwe: results from a systematic chart review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011748/
https://www.ncbi.nlm.nih.gov/pubmed/33788867
http://dx.doi.org/10.1371/journal.pone.0248423
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