Cargando…
Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review
A systematic chart review was performed to estimate the frequency of pregnancy outcomes, pregnancy complications and neonatal outcomes at facilities in Blantyre, Malawi; Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza and Harare, Zimbabwe to provide comparisons with estimates from an on...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011748/ https://www.ncbi.nlm.nih.gov/pubmed/33788867 http://dx.doi.org/10.1371/journal.pone.0248423 |
_version_ | 1783673267279626240 |
---|---|
author | Balkus, Jennifer E. Neradilek, Moni Fairlie, Lee Makanani, Bonus Mgodi, Nyaradzo Mhlanga, Felix Nakabiito, Clemensia Mayo, Ashley Harrell, Tanya Piper, Jeanna Bunge, Katherine E. |
author_facet | Balkus, Jennifer E. Neradilek, Moni Fairlie, Lee Makanani, Bonus Mgodi, Nyaradzo Mhlanga, Felix Nakabiito, Clemensia Mayo, Ashley Harrell, Tanya Piper, Jeanna Bunge, Katherine E. |
author_sort | Balkus, Jennifer E. |
collection | PubMed |
description | A systematic chart review was performed to estimate the frequency of pregnancy outcomes, pregnancy complications and neonatal outcomes at facilities in Blantyre, Malawi; Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza and Harare, Zimbabwe to provide comparisons with estimates from an ongoing clinical trial evaluating the safety of two biomedical HIV prevention interventions in pregnancy. A multi-site, cross-sectional chart review was conducted at Maternal Obstetric Units and hospitals where women participating in the ongoing clinical trial would be expected to deliver. All individuals delivering at the designated facilities or admitted for postpartum care within seven days of a delivery elsewhere (home, health clinic, etc.) were included in the review. Data were abstracted for pregnancy outcomes, pregnancy complications, maternal and neonatal death, and congenital anomalies. Data from 10,138 records were abstracted across all four sites (Blantyre n = 2,384; Johannesburg n = 1,888; Kampala n = 3,708; Chitungwiza and Harare n = 2,158), which included 10,426 pregnancy outcomes. The prevalence of preterm birth was 13% (range across sites: 10.4–20.7) and 4.1% of deliveries resulted in stillbirth (range: 3.1–5.5). The most commonly noted pregnancy complication was gestational hypertension, reported among 4.4% of pregnancies. Among pregnancies resulting in a live birth, 15.5% were low birthweight (range: 13.8–17.4) and 2.0% resulted in neonatal death (range:1.2–3.2). Suspected congenital anomalies were noted in 1.2% of pregnancies. This study provides systematically collected data on background rates of pregnancy outcomes, pregnancy complications and neonatal outcomes that can be used as a reference in support of ongoing HIV prevention studies. In addition, estimates from this study provide important background data for future studies of investigational products evaluated in pregnancy in these urban settings. |
format | Online Article Text |
id | pubmed-8011748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80117482021-04-07 Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review Balkus, Jennifer E. Neradilek, Moni Fairlie, Lee Makanani, Bonus Mgodi, Nyaradzo Mhlanga, Felix Nakabiito, Clemensia Mayo, Ashley Harrell, Tanya Piper, Jeanna Bunge, Katherine E. PLoS One Research Article A systematic chart review was performed to estimate the frequency of pregnancy outcomes, pregnancy complications and neonatal outcomes at facilities in Blantyre, Malawi; Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza and Harare, Zimbabwe to provide comparisons with estimates from an ongoing clinical trial evaluating the safety of two biomedical HIV prevention interventions in pregnancy. A multi-site, cross-sectional chart review was conducted at Maternal Obstetric Units and hospitals where women participating in the ongoing clinical trial would be expected to deliver. All individuals delivering at the designated facilities or admitted for postpartum care within seven days of a delivery elsewhere (home, health clinic, etc.) were included in the review. Data were abstracted for pregnancy outcomes, pregnancy complications, maternal and neonatal death, and congenital anomalies. Data from 10,138 records were abstracted across all four sites (Blantyre n = 2,384; Johannesburg n = 1,888; Kampala n = 3,708; Chitungwiza and Harare n = 2,158), which included 10,426 pregnancy outcomes. The prevalence of preterm birth was 13% (range across sites: 10.4–20.7) and 4.1% of deliveries resulted in stillbirth (range: 3.1–5.5). The most commonly noted pregnancy complication was gestational hypertension, reported among 4.4% of pregnancies. Among pregnancies resulting in a live birth, 15.5% were low birthweight (range: 13.8–17.4) and 2.0% resulted in neonatal death (range:1.2–3.2). Suspected congenital anomalies were noted in 1.2% of pregnancies. This study provides systematically collected data on background rates of pregnancy outcomes, pregnancy complications and neonatal outcomes that can be used as a reference in support of ongoing HIV prevention studies. In addition, estimates from this study provide important background data for future studies of investigational products evaluated in pregnancy in these urban settings. Public Library of Science 2021-03-31 /pmc/articles/PMC8011748/ /pubmed/33788867 http://dx.doi.org/10.1371/journal.pone.0248423 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Balkus, Jennifer E. Neradilek, Moni Fairlie, Lee Makanani, Bonus Mgodi, Nyaradzo Mhlanga, Felix Nakabiito, Clemensia Mayo, Ashley Harrell, Tanya Piper, Jeanna Bunge, Katherine E. Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review |
title | Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review |
title_full | Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review |
title_fullStr | Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review |
title_full_unstemmed | Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review |
title_short | Assessing pregnancy and neonatal outcomes in Malawi, South Africa, Uganda, and Zimbabwe: Results from a systematic chart review |
title_sort | assessing pregnancy and neonatal outcomes in malawi, south africa, uganda, and zimbabwe: results from a systematic chart review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011748/ https://www.ncbi.nlm.nih.gov/pubmed/33788867 http://dx.doi.org/10.1371/journal.pone.0248423 |
work_keys_str_mv | AT balkusjennifere assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT neradilekmoni assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT fairlielee assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT makananibonus assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT mgodinyaradzo assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT mhlangafelix assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT nakabiitoclemensia assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT mayoashley assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT harrelltanya assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT piperjeanna assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT bungekatherinee assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview AT assessingpregnancyandneonataloutcomesinmalawisouthafricaugandaandzimbabweresultsfromasystematicchartreview |