Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

[Image: see text] In this paper, the benzo-cracking approach was applied to the potent sigma1 (σ(1)) receptor antagonist 1 to afford the less conformationally constrained 1,3-dioxane derivatives 2 and 3. To evaluate the effect of the increase in the distance between the two hydrophobic structural el...

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Detalles Bibliográficos
Autores principales: Cifani, Carlo, Micioni Di Bonaventura, Emanuela, Botticelli, Luca, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Piergentili, Alessandro, Quaglia, Wilma, Bonifazi, Alessandro, Schepmann, Dirk, Wünsch, Bernhard, Vistoli, Giulio, Micioni Di Bonaventura, Maria Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011929/
https://www.ncbi.nlm.nih.gov/pubmed/32886484
http://dx.doi.org/10.1021/acschemneuro.0c00456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011929/
https://www.ncbi.nlm.nih.gov/pubmed/32886484
http://dx.doi.org/10.1021/acschemneuro.0c00456

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