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Identification, Structure–Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators

[Image: see text] Cystic fibrosis (CF) is a life-threatening autosomal recessive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR modulators have been reported to address the basic defects associated with CF-causing mutations, partially restori...

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Detalles Bibliográficos
Autores principales:	Brindani, Nicoletta, Gianotti, Ambra, Giovani, Simone, Giacomina, Francesca, Di Fruscia, Paolo, Sorana, Federico, Bertozzi, Sine Mandrup, Ottonello, Giuliana, Goldoni, Luca, Penna, Ilaria, Russo, Debora, Summa, Maria, Bertorelli, Rosalia, Ferrera, Loretta, Pesce, Emanuela, Sondo, Elvira, Galietta, Luis J. V., Bandiera, Tiziano, Pedemonte, Nicoletta, Bertozzi, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011931/ https://www.ncbi.nlm.nih.gov/pubmed/32946228 http://dx.doi.org/10.1021/acs.jmedchem.0c01050

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