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Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults

INTRODUCTION: The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of major depressive disorder (MDD) or MCI. METHODS: We included 37...

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Autores principales: Diniz, Breno S., Vieira, Erica M., Mendes‐Silva, Ana Paula, Bowie, Christopher R., Butters, Meryl A., Fischer, Corinne E., Flint, Alastair, Herrmann, Nathan, Kennedy, James, Lanctôt, Krista L., Mah, Linda, Pollock, Bruce G., Mulsant, Benoit H., Rajji, Tarek K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012242/
https://www.ncbi.nlm.nih.gov/pubmed/33816758
http://dx.doi.org/10.1002/trc2.12129
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author Diniz, Breno S.
Vieira, Erica M.
Mendes‐Silva, Ana Paula
Bowie, Christopher R.
Butters, Meryl A.
Fischer, Corinne E.
Flint, Alastair
Herrmann, Nathan
Kennedy, James
Lanctôt, Krista L.
Mah, Linda
Pollock, Bruce G.
Mulsant, Benoit H.
Rajji, Tarek K.
author_facet Diniz, Breno S.
Vieira, Erica M.
Mendes‐Silva, Ana Paula
Bowie, Christopher R.
Butters, Meryl A.
Fischer, Corinne E.
Flint, Alastair
Herrmann, Nathan
Kennedy, James
Lanctôt, Krista L.
Mah, Linda
Pollock, Bruce G.
Mulsant, Benoit H.
Rajji, Tarek K.
author_sort Diniz, Breno S.
collection PubMed
description INTRODUCTION: The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of major depressive disorder (MDD) or MCI. METHODS: We included 371 participants: 167 with MCI; 62 cognitively normal with a history of MDD; 97 with MDD+MCI; and 45 cognitively unimpaired (CU) without a history of MDD. The candidate Senescence‐Associated Secretory Phenotype (SASP) biomarkers were measured in the plasma using a customized LUMINEX assay. RESULTS: The MDD+MCI group had a higher SASP index than the other groups (P < .001). A higher SASP index was significantly associated with worse global cognitive performance, executive dysfunction, slower processing speed, and episodic memory deficits. DISCUSSION: Our study suggests that increased molecular changes are associated with cognitive impairment in older adults with MDD and indicate that accelerated biological aging is an underlying feature of MDD.
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spelling pubmed-80122422021-04-02 Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults Diniz, Breno S. Vieira, Erica M. Mendes‐Silva, Ana Paula Bowie, Christopher R. Butters, Meryl A. Fischer, Corinne E. Flint, Alastair Herrmann, Nathan Kennedy, James Lanctôt, Krista L. Mah, Linda Pollock, Bruce G. Mulsant, Benoit H. Rajji, Tarek K. Alzheimers Dement (N Y) Research Articles INTRODUCTION: The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of major depressive disorder (MDD) or MCI. METHODS: We included 371 participants: 167 with MCI; 62 cognitively normal with a history of MDD; 97 with MDD+MCI; and 45 cognitively unimpaired (CU) without a history of MDD. The candidate Senescence‐Associated Secretory Phenotype (SASP) biomarkers were measured in the plasma using a customized LUMINEX assay. RESULTS: The MDD+MCI group had a higher SASP index than the other groups (P < .001). A higher SASP index was significantly associated with worse global cognitive performance, executive dysfunction, slower processing speed, and episodic memory deficits. DISCUSSION: Our study suggests that increased molecular changes are associated with cognitive impairment in older adults with MDD and indicate that accelerated biological aging is an underlying feature of MDD. John Wiley and Sons Inc. 2021-03-31 /pmc/articles/PMC8012242/ /pubmed/33816758 http://dx.doi.org/10.1002/trc2.12129 Text en © 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Diniz, Breno S.
Vieira, Erica M.
Mendes‐Silva, Ana Paula
Bowie, Christopher R.
Butters, Meryl A.
Fischer, Corinne E.
Flint, Alastair
Herrmann, Nathan
Kennedy, James
Lanctôt, Krista L.
Mah, Linda
Pollock, Bruce G.
Mulsant, Benoit H.
Rajji, Tarek K.
Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
title Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
title_full Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
title_fullStr Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
title_full_unstemmed Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
title_short Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
title_sort mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012242/
https://www.ncbi.nlm.nih.gov/pubmed/33816758
http://dx.doi.org/10.1002/trc2.12129
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