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Nucleotide spacing distribution analysis for human genome

The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results...

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Detalles Bibliográficos
Autores principales: Górski, Andrzej Z., Piwowar, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012312/
https://www.ncbi.nlm.nih.gov/pubmed/33723659
http://dx.doi.org/10.1007/s00335-021-09865-5
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author Górski, Andrzej Z.
Piwowar, Monika
author_facet Górski, Andrzej Z.
Piwowar, Monika
author_sort Górski, Andrzej Z.
collection PubMed
description The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results nevertheless revealed several characteristic features: (i) the distribution for short-range spacing is quite similar to the purely stochastic sequences; (ii) the distribution for long-range spacing essentially deviates from the random sequence distribution, showing strong long-range correlations; (iii) the differences between (A, T) and (C, G) nucleotides are quite significant; (iv) the spacing distribution displays tiny oscillations.
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spelling pubmed-80123122021-04-16 Nucleotide spacing distribution analysis for human genome Górski, Andrzej Z. Piwowar, Monika Mamm Genome Article The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results nevertheless revealed several characteristic features: (i) the distribution for short-range spacing is quite similar to the purely stochastic sequences; (ii) the distribution for long-range spacing essentially deviates from the random sequence distribution, showing strong long-range correlations; (iii) the differences between (A, T) and (C, G) nucleotides are quite significant; (iv) the spacing distribution displays tiny oscillations. Springer US 2021-03-15 2021 /pmc/articles/PMC8012312/ /pubmed/33723659 http://dx.doi.org/10.1007/s00335-021-09865-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Górski, Andrzej Z.
Piwowar, Monika
Nucleotide spacing distribution analysis for human genome
title Nucleotide spacing distribution analysis for human genome
title_full Nucleotide spacing distribution analysis for human genome
title_fullStr Nucleotide spacing distribution analysis for human genome
title_full_unstemmed Nucleotide spacing distribution analysis for human genome
title_short Nucleotide spacing distribution analysis for human genome
title_sort nucleotide spacing distribution analysis for human genome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012312/
https://www.ncbi.nlm.nih.gov/pubmed/33723659
http://dx.doi.org/10.1007/s00335-021-09865-5
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