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Nucleotide spacing distribution analysis for human genome
The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012312/ https://www.ncbi.nlm.nih.gov/pubmed/33723659 http://dx.doi.org/10.1007/s00335-021-09865-5 |
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author | Górski, Andrzej Z. Piwowar, Monika |
author_facet | Górski, Andrzej Z. Piwowar, Monika |
author_sort | Górski, Andrzej Z. |
collection | PubMed |
description | The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results nevertheless revealed several characteristic features: (i) the distribution for short-range spacing is quite similar to the purely stochastic sequences; (ii) the distribution for long-range spacing essentially deviates from the random sequence distribution, showing strong long-range correlations; (iii) the differences between (A, T) and (C, G) nucleotides are quite significant; (iv) the spacing distribution displays tiny oscillations. |
format | Online Article Text |
id | pubmed-8012312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-80123122021-04-16 Nucleotide spacing distribution analysis for human genome Górski, Andrzej Z. Piwowar, Monika Mamm Genome Article The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results nevertheless revealed several characteristic features: (i) the distribution for short-range spacing is quite similar to the purely stochastic sequences; (ii) the distribution for long-range spacing essentially deviates from the random sequence distribution, showing strong long-range correlations; (iii) the differences between (A, T) and (C, G) nucleotides are quite significant; (iv) the spacing distribution displays tiny oscillations. Springer US 2021-03-15 2021 /pmc/articles/PMC8012312/ /pubmed/33723659 http://dx.doi.org/10.1007/s00335-021-09865-5 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Górski, Andrzej Z. Piwowar, Monika Nucleotide spacing distribution analysis for human genome |
title | Nucleotide spacing distribution analysis for human genome |
title_full | Nucleotide spacing distribution analysis for human genome |
title_fullStr | Nucleotide spacing distribution analysis for human genome |
title_full_unstemmed | Nucleotide spacing distribution analysis for human genome |
title_short | Nucleotide spacing distribution analysis for human genome |
title_sort | nucleotide spacing distribution analysis for human genome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012312/ https://www.ncbi.nlm.nih.gov/pubmed/33723659 http://dx.doi.org/10.1007/s00335-021-09865-5 |
work_keys_str_mv | AT gorskiandrzejz nucleotidespacingdistributionanalysisforhumangenome AT piwowarmonika nucleotidespacingdistributionanalysisforhumangenome |