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A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment

BACKGROUND: The Elipse™ intragastric balloon (EIGB) is a new swallowable balloon for weight loss (WL). Preserving metabolically active fat-free mass (FFM) and resting metabolic rate (RMR) during WL are crucial to maximize fat mass (FM) loss. After EIGB placement, a standard low-calorie diet (LCD) is...

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Autores principales: Schiavo, Luigi, De Stefano, Giovanni, Persico, Francesco, Gargiulo, Stefano, Di Spirito, Federica, Griguolo, Giulia, Petrucciani, Niccolò, Fontas, Eric, Iannelli, Antonio, Pilone, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012342/
https://www.ncbi.nlm.nih.gov/pubmed/33215362
http://dx.doi.org/10.1007/s11695-020-05133-8
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author Schiavo, Luigi
De Stefano, Giovanni
Persico, Francesco
Gargiulo, Stefano
Di Spirito, Federica
Griguolo, Giulia
Petrucciani, Niccolò
Fontas, Eric
Iannelli, Antonio
Pilone, Vincenzo
author_facet Schiavo, Luigi
De Stefano, Giovanni
Persico, Francesco
Gargiulo, Stefano
Di Spirito, Federica
Griguolo, Giulia
Petrucciani, Niccolò
Fontas, Eric
Iannelli, Antonio
Pilone, Vincenzo
author_sort Schiavo, Luigi
collection PubMed
description BACKGROUND: The Elipse™ intragastric balloon (EIGB) is a new swallowable balloon for weight loss (WL). Preserving metabolically active fat-free mass (FFM) and resting metabolic rate (RMR) during WL are crucial to maximize fat mass (FM) loss. After EIGB placement, a standard low-calorie diet (LCD) is generally prescribed. A low-calorie ketogenic diet (LCKD) has proven to be safe and effective in reducing FM while preserving FFM and RMR. OBJECTIVE: To prospectively compare the effects on WL, FM, FFM, and RMR in two groups of patients who were randomized to two different diets: LCKD and a standard LCD after EIGB placement. METHODS: WL, FM, FFM, and RMR were measured before EIGB and at 4 months in 48 patients who received either a LCKD (n = 24) or a standard LCD (n = 24). Compliance in following the prescribed diet was determined with food frequency questionnaires in all patients. The impact of LCKD and LCD on renal function was also evaluated. RESULTS: The LCKD group showed a significantly lower decrease in FFM and RMR when compared with the LCD group (3.55 vs 14.3%, p < 0.001; 9.79 vs 11.4%, p < 0.001, respectively). FM decreased more significantly with LCKD compared to LCD (41.6 vs 33.1%, p = 0.0606). Compliance in following the prescribed diets, without negative impact on renal function, was found. CONCLUSION: Based on our findings, despite the small sample size, we were able to support the hypothesis that LCKD is associated with an increased FM loss while reducing the FFM loss and the RMR, without interfering with renal function after EIGB.
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spelling pubmed-80123422021-04-16 A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment Schiavo, Luigi De Stefano, Giovanni Persico, Francesco Gargiulo, Stefano Di Spirito, Federica Griguolo, Giulia Petrucciani, Niccolò Fontas, Eric Iannelli, Antonio Pilone, Vincenzo Obes Surg Original Contributions BACKGROUND: The Elipse™ intragastric balloon (EIGB) is a new swallowable balloon for weight loss (WL). Preserving metabolically active fat-free mass (FFM) and resting metabolic rate (RMR) during WL are crucial to maximize fat mass (FM) loss. After EIGB placement, a standard low-calorie diet (LCD) is generally prescribed. A low-calorie ketogenic diet (LCKD) has proven to be safe and effective in reducing FM while preserving FFM and RMR. OBJECTIVE: To prospectively compare the effects on WL, FM, FFM, and RMR in two groups of patients who were randomized to two different diets: LCKD and a standard LCD after EIGB placement. METHODS: WL, FM, FFM, and RMR were measured before EIGB and at 4 months in 48 patients who received either a LCKD (n = 24) or a standard LCD (n = 24). Compliance in following the prescribed diet was determined with food frequency questionnaires in all patients. The impact of LCKD and LCD on renal function was also evaluated. RESULTS: The LCKD group showed a significantly lower decrease in FFM and RMR when compared with the LCD group (3.55 vs 14.3%, p < 0.001; 9.79 vs 11.4%, p < 0.001, respectively). FM decreased more significantly with LCKD compared to LCD (41.6 vs 33.1%, p = 0.0606). Compliance in following the prescribed diets, without negative impact on renal function, was found. CONCLUSION: Based on our findings, despite the small sample size, we were able to support the hypothesis that LCKD is associated with an increased FM loss while reducing the FFM loss and the RMR, without interfering with renal function after EIGB. Springer US 2020-11-20 2021 /pmc/articles/PMC8012342/ /pubmed/33215362 http://dx.doi.org/10.1007/s11695-020-05133-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Contributions
Schiavo, Luigi
De Stefano, Giovanni
Persico, Francesco
Gargiulo, Stefano
Di Spirito, Federica
Griguolo, Giulia
Petrucciani, Niccolò
Fontas, Eric
Iannelli, Antonio
Pilone, Vincenzo
A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment
title A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment
title_full A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment
title_fullStr A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment
title_full_unstemmed A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment
title_short A Randomized, Controlled Trial Comparing the Impact of a Low-Calorie Ketogenic vs a Standard Low-Calorie Diet on Fat-Free Mass in Patients Receiving an Elipse™ Intragastric Balloon Treatment
title_sort randomized, controlled trial comparing the impact of a low-calorie ketogenic vs a standard low-calorie diet on fat-free mass in patients receiving an elipse™ intragastric balloon treatment
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012342/
https://www.ncbi.nlm.nih.gov/pubmed/33215362
http://dx.doi.org/10.1007/s11695-020-05133-8
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