DOT1L inhibitors block abnormal self-renewal induced by cohesin loss

Acute myeloid leukemia (AML) is a high-risk malignancy characterized by a diverse spectrum of somatic genetic alterations. The mechanisms by which these mutations contribute to leukemia development and how this informs the use of targeted therapies is critical to improving outcomes for patients. Imp...

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Detalles Bibliográficos
Autores principales: Heimbruch, Katelyn E., Fisher, Joseph B., Stelloh, Cary T., Phillips, Emily, Reimer, Michael H., Wargolet, Adam J., Meyer, Alison E., Pulakanti, Kirthi, Viny, Aaron D., Loppnow, Jessica J., Levine, Ross L., Pulikkan, John Anto, Zhu, Nan, Rao, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012605/
https://www.ncbi.nlm.nih.gov/pubmed/33790356
http://dx.doi.org/10.1038/s41598-021-86646-9

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