cGAS–STING cytosolic DNA sensing pathway is suppressed by JAK2-STAT3 in tumor cells

Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here, we show that the cGAS-STING pathway was unresponsive to STING agonists and fa...

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Detalles Bibliográficos
Autores principales: Suter, Manuel Adrian, Tan, Nikki Y., Thiam, Chung Hwee, Khatoo, Muznah, MacAry, Paul A., Angeli, Veronique, Gasser, Stephan, Zhang, Y. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012641/
https://www.ncbi.nlm.nih.gov/pubmed/33790360
http://dx.doi.org/10.1038/s41598-021-86644-x

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