Cargando…

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Natarajan, Gayathri K., Mishra, Jyotsna, Camara, Amadou K. S., Kwok, Wai-Meng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012663/ https://www.ncbi.nlm.nih.gov/pubmed/33815143 http://dx.doi.org/10.3389/fphys.2021.637852

Ejemplares similares

Total Matrix Ca(2+) Modulates Ca(2+) Efflux via the Ca(2+)/H(+) Exchanger in Cardiac Mitochondria
por: Natarajan, Gayathri K., et al.
Publicado: (2020)

LETM1 in mitochondrial cation transport
por: Nowikovsky, Karin, et al.
Publicado: (2014)

Cyclosporin A Increases Mitochondrial Buffering of Calcium: An Additional Mechanism in Delaying Mitochondrial Permeability Transition Pore Opening
por: Mishra, Jyotsna, et al.
Publicado: (2019)

Editorial: Mitochondrial Exchangers and Transporters in Cell Survival and Death
por: Kwok, Wai-Meng, et al.
Publicado: (2021)

Mitochondria: hubs of cellular signaling, energetics and redox balance. A rich, vibrant, and diverse landscape of mitochondrial research
por: Aon, Miguel A., et al.
Publicado: (2015)

LETM1-Mediated K(+) and Na(+) Homeostasis Regulates Mitochondrial Ca(2+) Efflux
por: Austin, Shane, et al.
Publicado: (2017)

LETM1 is required for mitochondrial homeostasis and cellular viability
por: Li, Yuwen, et al.
Publicado: (2019)

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
por: Camara, Amadou K. S., et al.
Publicado: (2017)

LETM1 couples mitochondrial DNA metabolism and nutrient preference
por: Durigon, Romina, et al.
Publicado: (2018)

The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain
por: Nakamura, Seiko, et al.
Publicado: (2020)

Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
por: Haloi, Nandan, et al.
Publicado: (2021)

The Pathophysiology of LETM1
por: Nowikovsky, Karin, et al.
Publicado: (2012)

Mitochondrial Approaches to Protect Against Cardiac Ischemia and Reperfusion Injury
por: Camara, Amadou K. S., et al.
Publicado: (2011)

Hypothermia Prevents Cardiac Dysfunction during Acute Ischemia Reperfusion by Maintaining Mitochondrial Bioenergetics and by Promoting Hexokinase II Binding to Mitochondria
por: Sun, Jie, et al.
Publicado: (2022)

Slow Ca(2+) Efflux by Ca(2+)/H(+) Exchange in Cardiac Mitochondria Is Modulated by Ca(2+) Re-uptake via MCU, Extra-Mitochondrial pH, and H(+) Pumping by F(O)F(1)-ATPase
por: Haumann, Johan, et al.
Publicado: (2019)

Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury
por: Agarwal, Bhawana, et al.
Publicado: (2014)

Functional reconstitution of the mitochondrial Ca(2+)/H(+) antiporter Letm1
por: Tsai, Ming-Feng, et al.
Publicado: (2014)

Differential effects of buffer pH on Ca(2+)-induced ROS emission with inhibited mitochondrial complexes I and III
por: Lindsay, Daniel P., et al.
Publicado: (2015)

LETM presented with causalgia and ensued by sudden death
por: Alsukhni, Rana Alnasser, et al.
Publicado: (2017)

PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress
por: Huang, En, et al.
Publicado: (2017)

Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia
por: Sánchez-Aranguren, Lissette C., et al.
Publicado: (2018)

Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?
por: Huang, Xin, et al.
Publicado: (2021)

Mitochondrial and cellular mechanisms for managing lipid excess
por: Aon, Miguel A., et al.
Publicado: (2014)

Role of Methyl Prednisolone in Longitudinal Extensive Transverse Myelitis (LETM) in Children
por: Ashfaq, Muhammad Azeem, et al.
Publicado: (2020)

Emerging role of LETM1/GRP78 axis in lung cancer
por: Tran, Quangdon, et al.
Publicado: (2022)

Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress
por: Yang, Meiying, et al.
Publicado: (2020)

Tubercular longitudinally extensive transverse myelitis (LETM): An enigma for primary care physicians
por: Anand, Kumar Abhishek, et al.
Publicado: (2021)

Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin
por: Quiles, Justin M., et al.
Publicado: (2020)

Longitudinal extensive transverse myelitis (LETM) in children: A twenty-year study from Oman
por: Koul, Roshan, et al.
Publicado: (2017)

Mitochondrial uncoupling proteins and energy metabolism
por: Busiello, Rosa A., et al.
Publicado: (2015)

LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition
por: Hart, Lesley, et al.
Publicado: (2014)

Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement
por: Kaiyrzhanov, Rauan, et al.
Publicado: (2022)

A rare association of tuberculous longitudinally extensive transverse myelitis (LETM) with brain tuberculoma
por: Jain, Rajendra Singh, et al.
Publicado: (2015)

Knockdown of LETM1 inhibits proliferation and metastasis of human renal cell carcinoma cells
por: Xu, Jie, et al.
Publicado: (2018)

Post COVID-19 longitudinally extensive transverse myelitis (LETM)–a case report
por: Baghbanian, Seyed Mohammad, et al.
Publicado: (2020)

LETM1 is a potential biomarker of prognosis in lung non-small cell carcinoma
por: Piao, Longzhen, et al.
Publicado: (2019)

Mitochondrial and Metabolic Gene Expression in the Aged Rat Heart
por: Barton, Gregory P., et al.
Publicado: (2016)

Editorial: Mitochondrial bioenergetics impairments in genetic and metabolic diseases
por: Bergamini, Christian, et al.
Publicado: (2023)

Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer
por: Roy, Mahua, et al.
Publicado: (2017)

The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish
por: Dao, Pauline, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u8o9ucv094uml5dt7ia5ps1gr9