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Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model
Aging increases the risk for neurodegenerative disease and brain trauma, both leading to irreversible and multifaceted deficits that impose a clear societal and economic burden onto the growing world population. Despite tremendous research efforts, there are still no treatments available that can fu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012675/ https://www.ncbi.nlm.nih.gov/pubmed/33816468 http://dx.doi.org/10.3389/fcell.2021.619197 |
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author | Van houcke, Jolien Mariën, Valerie Zandecki, Caroline Seuntjens, Eve Ayana, Rajagopal Arckens, Lutgarde |
author_facet | Van houcke, Jolien Mariën, Valerie Zandecki, Caroline Seuntjens, Eve Ayana, Rajagopal Arckens, Lutgarde |
author_sort | Van houcke, Jolien |
collection | PubMed |
description | Aging increases the risk for neurodegenerative disease and brain trauma, both leading to irreversible and multifaceted deficits that impose a clear societal and economic burden onto the growing world population. Despite tremendous research efforts, there are still no treatments available that can fully restore brain function, which would imply neuroregeneration. In the adult mammalian brain, neuroregeneration is naturally limited, even more so in an aging context. In view of the significant influence of aging on (late-onset) neurological disease, it is a critical factor in future research. This review discusses the use of a non-standard gerontology model, the teleost brain, for studying the impact of aging on neurorepair. Teleost fish share a vertebrate physiology with mammals, including mammalian-like aging, but in contrast to mammals have a high capacity for regeneration. Moreover, access to large mutagenesis screens empowers these teleost species to fill the gap between established invertebrate and rodent models. As such, we here highlight opportunities to decode the factor age in relation to neurorepair, and we propose the use of teleost fish, and in particular killifish, to fuel new research in the neuro-gerontology field. |
format | Online Article Text |
id | pubmed-8012675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80126752021-04-02 Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model Van houcke, Jolien Mariën, Valerie Zandecki, Caroline Seuntjens, Eve Ayana, Rajagopal Arckens, Lutgarde Front Cell Dev Biol Cell and Developmental Biology Aging increases the risk for neurodegenerative disease and brain trauma, both leading to irreversible and multifaceted deficits that impose a clear societal and economic burden onto the growing world population. Despite tremendous research efforts, there are still no treatments available that can fully restore brain function, which would imply neuroregeneration. In the adult mammalian brain, neuroregeneration is naturally limited, even more so in an aging context. In view of the significant influence of aging on (late-onset) neurological disease, it is a critical factor in future research. This review discusses the use of a non-standard gerontology model, the teleost brain, for studying the impact of aging on neurorepair. Teleost fish share a vertebrate physiology with mammals, including mammalian-like aging, but in contrast to mammals have a high capacity for regeneration. Moreover, access to large mutagenesis screens empowers these teleost species to fill the gap between established invertebrate and rodent models. As such, we here highlight opportunities to decode the factor age in relation to neurorepair, and we propose the use of teleost fish, and in particular killifish, to fuel new research in the neuro-gerontology field. Frontiers Media S.A. 2021-03-18 /pmc/articles/PMC8012675/ /pubmed/33816468 http://dx.doi.org/10.3389/fcell.2021.619197 Text en Copyright © 2021 Van houcke, Mariën, Zandecki, Seuntjens, Ayana and Arckens. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Van houcke, Jolien Mariën, Valerie Zandecki, Caroline Seuntjens, Eve Ayana, Rajagopal Arckens, Lutgarde Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model |
title | Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model |
title_full | Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model |
title_fullStr | Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model |
title_full_unstemmed | Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model |
title_short | Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model |
title_sort | modeling neuroregeneration and neurorepair in an aging context: the power of a teleost model |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012675/ https://www.ncbi.nlm.nih.gov/pubmed/33816468 http://dx.doi.org/10.3389/fcell.2021.619197 |
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