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Ribosome Rescue Pathways in Bacteria

Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue pathways to remove the stalled ribosomes from the aberrant mRNA and return them to the free pool of actively translating ribos...

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Autores principales: Müller, Claudia, Crowe-McAuliffe, Caillan, Wilson, Daniel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012679/
https://www.ncbi.nlm.nih.gov/pubmed/33815344
http://dx.doi.org/10.3389/fmicb.2021.652980
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author Müller, Claudia
Crowe-McAuliffe, Caillan
Wilson, Daniel N.
author_facet Müller, Claudia
Crowe-McAuliffe, Caillan
Wilson, Daniel N.
author_sort Müller, Claudia
collection PubMed
description Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue pathways to remove the stalled ribosomes from the aberrant mRNA and return them to the free pool of actively translating ribosomes. In addition, some of these pathways target the damaged mRNA and the incomplete nascent polypeptide chain for degradation. This review highlights the recent developments in our mechanistic understanding of bacterial ribosomal rescue systems, including drop-off, trans-translation mediated by transfer-messenger RNA and small protein B, ribosome rescue by the alternative rescue factors ArfA and ArfB, as well as Bacillus ribosome rescue factor A, an additional rescue system found in some Gram-positive bacteria, such as Bacillus subtilis. Finally, we discuss the recent findings of ribosome-associated quality control in particular bacterial lineages mediated by RqcH and RqcP. The importance of rescue pathways for bacterial survival suggests they may represent novel targets for the development of new antimicrobial agents against multi-drug resistant pathogenic bacteria.
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spelling pubmed-80126792021-04-02 Ribosome Rescue Pathways in Bacteria Müller, Claudia Crowe-McAuliffe, Caillan Wilson, Daniel N. Front Microbiol Microbiology Ribosomes that become stalled on truncated or damaged mRNAs during protein synthesis must be rescued for the cell to survive. Bacteria have evolved a diverse array of rescue pathways to remove the stalled ribosomes from the aberrant mRNA and return them to the free pool of actively translating ribosomes. In addition, some of these pathways target the damaged mRNA and the incomplete nascent polypeptide chain for degradation. This review highlights the recent developments in our mechanistic understanding of bacterial ribosomal rescue systems, including drop-off, trans-translation mediated by transfer-messenger RNA and small protein B, ribosome rescue by the alternative rescue factors ArfA and ArfB, as well as Bacillus ribosome rescue factor A, an additional rescue system found in some Gram-positive bacteria, such as Bacillus subtilis. Finally, we discuss the recent findings of ribosome-associated quality control in particular bacterial lineages mediated by RqcH and RqcP. The importance of rescue pathways for bacterial survival suggests they may represent novel targets for the development of new antimicrobial agents against multi-drug resistant pathogenic bacteria. Frontiers Media S.A. 2021-03-18 /pmc/articles/PMC8012679/ /pubmed/33815344 http://dx.doi.org/10.3389/fmicb.2021.652980 Text en Copyright © 2021 Müller, Crowe-McAuliffe and Wilson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Müller, Claudia
Crowe-McAuliffe, Caillan
Wilson, Daniel N.
Ribosome Rescue Pathways in Bacteria
title Ribosome Rescue Pathways in Bacteria
title_full Ribosome Rescue Pathways in Bacteria
title_fullStr Ribosome Rescue Pathways in Bacteria
title_full_unstemmed Ribosome Rescue Pathways in Bacteria
title_short Ribosome Rescue Pathways in Bacteria
title_sort ribosome rescue pathways in bacteria
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012679/
https://www.ncbi.nlm.nih.gov/pubmed/33815344
http://dx.doi.org/10.3389/fmicb.2021.652980
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