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Functional Characterization of the Effects of N-acetyltransferase 2 Alleles on N-acetylation of Eight Drugs and Worldwide Distribution of Substrate-Specific Diversity
Variability in the enzymatic activity of N-acetyltransferase 2 (NAT2) is an important contributor to interindividual differences in drug responses. However, there is little information on functional differences in N-acetylation activities according to NAT2 phenotypes, i.e., rapid, intermediate, slow...
Autores principales: | Fukunaga, Koya, Kato, Ken, Okusaka, Takuji, Saito, Takeo, Ikeda, Masashi, Yoshida, Teruhiko, Zembutsu, Hitoshi, Iwata, Nakao, Mushiroda, Taisei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012690/ https://www.ncbi.nlm.nih.gov/pubmed/33815485 http://dx.doi.org/10.3389/fgene.2021.652704 |
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