Cargando…

Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study

Background: Lipids are known to accumulate abnormally in the alveoli and circulate during pulmonary alveolar proteinosis (PAP). However, the relationship between lipid ratios and PAP is not clear. In this study, we investigated the lipid ratios in PAP patients and explored the relationships between...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Xin, Gao, Yujuan, Zhao, Qi, Qiu, Xiaohua, Tian, Mi, Dai, Jinghong, Zhuang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012728/
https://www.ncbi.nlm.nih.gov/pubmed/33816536
http://dx.doi.org/10.3389/fnut.2021.610765
_version_ 1783673427061637120
author Yan, Xin
Gao, Yujuan
Zhao, Qi
Qiu, Xiaohua
Tian, Mi
Dai, Jinghong
Zhuang, Yi
author_facet Yan, Xin
Gao, Yujuan
Zhao, Qi
Qiu, Xiaohua
Tian, Mi
Dai, Jinghong
Zhuang, Yi
author_sort Yan, Xin
collection PubMed
description Background: Lipids are known to accumulate abnormally in the alveoli and circulate during pulmonary alveolar proteinosis (PAP). However, the relationship between lipid ratios and PAP is not clear. In this study, we investigated the lipid ratios in PAP patients and explored the relationships between lipid ratios and the severity of PAP. Methods: A total of 122 PAP patients were diagnosed and divided the mild- moderate PAP group (n = 61) and the severe PAP group (n = 61) according to the value of disease severity score (DSS). One hundred thirty healthy volunteers were classified as the control group. Routine blood examination and pulmonary function tests were performed and lipid profile were measured. Results: Compared with the control group, patients with PAP had significantly higher TG, TC/HDL-C, TG/HDL-C, and non-HDL-C, while lower HDL-C (all P < 0.05). Patients with the severe PAP had higher TC, TG, LDL-C, TC/HDL-C, and non-HDL-C, while lower HDL-C than patients with the mild- moderate PAP (all P < 0.05). Binary logistic regression analysis indicated that TC/HDL-C (OR = 2.322, 95% CI 1.621–3.713, P = 0.024) and non-HDL-C (OR = 1.797, 95% CI 1.239–3.109, P = 0.036) were all significantly correlated with the severity of PAP after adjustment for other risk factors. The AUC value of TC/HDL-C for predicting the severity of PAP was larger than that of non-HDL-C. The AUROC for TC/HDL-C was 0.741 (0.654–0.828), and the optimal cut-off point for TC/HDL-C was 5.05 (sensitivity: 73.6%, specificity: 68.1%). Conclusions: Lipid ratios, including TC-HDL-C and non-HDL-C, were independent risk factors for the severity of PAP. TC/HDL-C is a promising biomarker for the severity of PAP.
format Online
Article
Text
id pubmed-8012728
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80127282021-04-02 Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study Yan, Xin Gao, Yujuan Zhao, Qi Qiu, Xiaohua Tian, Mi Dai, Jinghong Zhuang, Yi Front Nutr Nutrition Background: Lipids are known to accumulate abnormally in the alveoli and circulate during pulmonary alveolar proteinosis (PAP). However, the relationship between lipid ratios and PAP is not clear. In this study, we investigated the lipid ratios in PAP patients and explored the relationships between lipid ratios and the severity of PAP. Methods: A total of 122 PAP patients were diagnosed and divided the mild- moderate PAP group (n = 61) and the severe PAP group (n = 61) according to the value of disease severity score (DSS). One hundred thirty healthy volunteers were classified as the control group. Routine blood examination and pulmonary function tests were performed and lipid profile were measured. Results: Compared with the control group, patients with PAP had significantly higher TG, TC/HDL-C, TG/HDL-C, and non-HDL-C, while lower HDL-C (all P < 0.05). Patients with the severe PAP had higher TC, TG, LDL-C, TC/HDL-C, and non-HDL-C, while lower HDL-C than patients with the mild- moderate PAP (all P < 0.05). Binary logistic regression analysis indicated that TC/HDL-C (OR = 2.322, 95% CI 1.621–3.713, P = 0.024) and non-HDL-C (OR = 1.797, 95% CI 1.239–3.109, P = 0.036) were all significantly correlated with the severity of PAP after adjustment for other risk factors. The AUC value of TC/HDL-C for predicting the severity of PAP was larger than that of non-HDL-C. The AUROC for TC/HDL-C was 0.741 (0.654–0.828), and the optimal cut-off point for TC/HDL-C was 5.05 (sensitivity: 73.6%, specificity: 68.1%). Conclusions: Lipid ratios, including TC-HDL-C and non-HDL-C, were independent risk factors for the severity of PAP. TC/HDL-C is a promising biomarker for the severity of PAP. Frontiers Media S.A. 2021-03-18 /pmc/articles/PMC8012728/ /pubmed/33816536 http://dx.doi.org/10.3389/fnut.2021.610765 Text en Copyright © 2021 Yan, Gao, Zhao, Qiu, Tian, Dai and Zhuang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Yan, Xin
Gao, Yujuan
Zhao, Qi
Qiu, Xiaohua
Tian, Mi
Dai, Jinghong
Zhuang, Yi
Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study
title Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study
title_full Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study
title_fullStr Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study
title_full_unstemmed Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study
title_short Correlation of Lipid Ratios With the Severity of Pulmonary Alveolar Proteinosis: A Cross-Sectional Study
title_sort correlation of lipid ratios with the severity of pulmonary alveolar proteinosis: a cross-sectional study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012728/
https://www.ncbi.nlm.nih.gov/pubmed/33816536
http://dx.doi.org/10.3389/fnut.2021.610765
work_keys_str_mv AT yanxin correlationoflipidratioswiththeseverityofpulmonaryalveolarproteinosisacrosssectionalstudy
AT gaoyujuan correlationoflipidratioswiththeseverityofpulmonaryalveolarproteinosisacrosssectionalstudy
AT zhaoqi correlationoflipidratioswiththeseverityofpulmonaryalveolarproteinosisacrosssectionalstudy
AT qiuxiaohua correlationoflipidratioswiththeseverityofpulmonaryalveolarproteinosisacrosssectionalstudy
AT tianmi correlationoflipidratioswiththeseverityofpulmonaryalveolarproteinosisacrosssectionalstudy
AT daijinghong correlationoflipidratioswiththeseverityofpulmonaryalveolarproteinosisacrosssectionalstudy
AT zhuangyi correlationoflipidratioswiththeseverityofpulmonaryalveolarproteinosisacrosssectionalstudy