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Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome

Rest-Activity circadian Rhythm (RAR) can be used as a marker of the circadian timing system. Recent studies investigated the relationship between irregular circadian rhythms and cardiovascular risk factors such as hypertension, obesity, and dyslipidemia. These factors are related to the Metabolic Sy...

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Autores principales: Mulè, Antonino, Bruno, Eleonora, Pasanisi, Patrizia, Galasso, Letizia, Castelli, Lucia, Caumo, Andrea, Esposito, Fabio, Roveda, Eliana, Montaruli, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013705/
https://www.ncbi.nlm.nih.gov/pubmed/33815145
http://dx.doi.org/10.3389/fphys.2021.641461
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author Mulè, Antonino
Bruno, Eleonora
Pasanisi, Patrizia
Galasso, Letizia
Castelli, Lucia
Caumo, Andrea
Esposito, Fabio
Roveda, Eliana
Montaruli, Angela
author_facet Mulè, Antonino
Bruno, Eleonora
Pasanisi, Patrizia
Galasso, Letizia
Castelli, Lucia
Caumo, Andrea
Esposito, Fabio
Roveda, Eliana
Montaruli, Angela
author_sort Mulè, Antonino
collection PubMed
description Rest-Activity circadian Rhythm (RAR) can be used as a marker of the circadian timing system. Recent studies investigated the relationship between irregular circadian rhythms and cardiovascular risk factors such as hypertension, obesity, and dyslipidemia. These factors are related to the Metabolic Syndrome (MS), a clustering of metabolic risk factors that increases the risk of several cardiovascular and metabolic diseases. This cross-sectional analysis aimed to explore the RAR characteristics by actigraphy in subjects with MS, particularly in relation to sex and MS parameters, using parametric and non-parametric analyses. Distinguishing the characteristics of RAR based on sex could prove useful as a tool to improve the daily level of activity and set up customized activity programs based on each person’s circadian activity profile. This study showed that female participants exhibited higher values than male participants in the Midline Estimating Statistic of Rhythm (MESOR) (243.3 ± 20.0 vs 197.6 ± 17.9 activity count), Amplitude (184.5 ± 18.5 vs 144.2 ± 17.2 activity count), which measures half of the extent of the rhythmic variation in a cycle, and the most active 10-h period (M10) (379.08 ± 16.43 vs 295.13 ± 12.88 activity count). All these parameters are indicative of a higher daily activity level in women. Female participants also had lower Intradaily Variability (IV) than male participants (0.75 ± 0.03 vs 0.85 ± 0.03 activity count), which indicates a more stable and less fragmented RAR. These preliminary data provide the first experimental evidence of a difference in RAR parameters between male and female people with MS.
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spelling pubmed-80137052021-04-02 Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome Mulè, Antonino Bruno, Eleonora Pasanisi, Patrizia Galasso, Letizia Castelli, Lucia Caumo, Andrea Esposito, Fabio Roveda, Eliana Montaruli, Angela Front Physiol Physiology Rest-Activity circadian Rhythm (RAR) can be used as a marker of the circadian timing system. Recent studies investigated the relationship between irregular circadian rhythms and cardiovascular risk factors such as hypertension, obesity, and dyslipidemia. These factors are related to the Metabolic Syndrome (MS), a clustering of metabolic risk factors that increases the risk of several cardiovascular and metabolic diseases. This cross-sectional analysis aimed to explore the RAR characteristics by actigraphy in subjects with MS, particularly in relation to sex and MS parameters, using parametric and non-parametric analyses. Distinguishing the characteristics of RAR based on sex could prove useful as a tool to improve the daily level of activity and set up customized activity programs based on each person’s circadian activity profile. This study showed that female participants exhibited higher values than male participants in the Midline Estimating Statistic of Rhythm (MESOR) (243.3 ± 20.0 vs 197.6 ± 17.9 activity count), Amplitude (184.5 ± 18.5 vs 144.2 ± 17.2 activity count), which measures half of the extent of the rhythmic variation in a cycle, and the most active 10-h period (M10) (379.08 ± 16.43 vs 295.13 ± 12.88 activity count). All these parameters are indicative of a higher daily activity level in women. Female participants also had lower Intradaily Variability (IV) than male participants (0.75 ± 0.03 vs 0.85 ± 0.03 activity count), which indicates a more stable and less fragmented RAR. These preliminary data provide the first experimental evidence of a difference in RAR parameters between male and female people with MS. Frontiers Media S.A. 2021-03-18 /pmc/articles/PMC8013705/ /pubmed/33815145 http://dx.doi.org/10.3389/fphys.2021.641461 Text en Copyright © 2021 Mulè, Bruno, Pasanisi, Galasso, Castelli, Caumo, Esposito, Roveda and Montaruli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Mulè, Antonino
Bruno, Eleonora
Pasanisi, Patrizia
Galasso, Letizia
Castelli, Lucia
Caumo, Andrea
Esposito, Fabio
Roveda, Eliana
Montaruli, Angela
Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome
title Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome
title_full Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome
title_fullStr Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome
title_full_unstemmed Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome
title_short Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome
title_sort sex differences in rest-activity circadian rhythm in patients with metabolic syndrome
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013705/
https://www.ncbi.nlm.nih.gov/pubmed/33815145
http://dx.doi.org/10.3389/fphys.2021.641461
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