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Chemical stability of oil-infused polyethylene

Ultra-high molecular weight polyethylene (UHMWPE) can be made radiopaque for medical imaging applications through the diffusion of an iodised oil-based contrast agent (Lipiodol Ultra Fluid). A similar process is used for Vitamin E incorporated polyethylene which provides antioxidant properties. This...

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Autores principales: Zaribaf, Fedra P, Gill, Harinderjit S, Pegg, Elise C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013815/
https://www.ncbi.nlm.nih.gov/pubmed/33356787
http://dx.doi.org/10.1177/0885328220977353
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author Zaribaf, Fedra P
Gill, Harinderjit S
Pegg, Elise C
author_facet Zaribaf, Fedra P
Gill, Harinderjit S
Pegg, Elise C
author_sort Zaribaf, Fedra P
collection PubMed
description Ultra-high molecular weight polyethylene (UHMWPE) can be made radiopaque for medical imaging applications through the diffusion of an iodised oil-based contrast agent (Lipiodol Ultra Fluid). A similar process is used for Vitamin E incorporated polyethylene which provides antioxidant properties. This study aimed to investigate the critical long-term properties of oil-infused medical polyethylene after 4 weeks of accelerated thermal ageing. Samples treated with an oil (Vitamin E or Lipiodol) had a higher oxidation stability than currently used medical grade polyethylene, indicated by a smaller increase in oxidation index after ageing (Vitamin E + 36%, Lipiodol +40%, Untreated +136%, Thermally treated +164%). The tensile properties of oil treated polyethylene after ageing were significantly higher than the Untreated and Thermally treated controls (p<0.05) indicating less mechanical degradation. There was also no alteration in the percentage crystallinity of oil treated samples after ageing, though the radiopacity of the Lipiodol treated samples reduced by 54% after ageing. The leaching of oil with time was also investigated; the leaching of Lipiodol and Vitamin E followed the same trend and reached a steady state by two weeks. Overall, it can be concluded that the diffusion of an oil-based fluid into polyethylene not only increases the oxidative and chemical stability of polyethylene but also adds additional functionality (e.g. radiopacity) providing a more suitable material for long–term medical applications.
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spelling pubmed-80138152021-04-16 Chemical stability of oil-infused polyethylene Zaribaf, Fedra P Gill, Harinderjit S Pegg, Elise C J Biomater Appl Biomaterials Processing Ultra-high molecular weight polyethylene (UHMWPE) can be made radiopaque for medical imaging applications through the diffusion of an iodised oil-based contrast agent (Lipiodol Ultra Fluid). A similar process is used for Vitamin E incorporated polyethylene which provides antioxidant properties. This study aimed to investigate the critical long-term properties of oil-infused medical polyethylene after 4 weeks of accelerated thermal ageing. Samples treated with an oil (Vitamin E or Lipiodol) had a higher oxidation stability than currently used medical grade polyethylene, indicated by a smaller increase in oxidation index after ageing (Vitamin E + 36%, Lipiodol +40%, Untreated +136%, Thermally treated +164%). The tensile properties of oil treated polyethylene after ageing were significantly higher than the Untreated and Thermally treated controls (p<0.05) indicating less mechanical degradation. There was also no alteration in the percentage crystallinity of oil treated samples after ageing, though the radiopacity of the Lipiodol treated samples reduced by 54% after ageing. The leaching of oil with time was also investigated; the leaching of Lipiodol and Vitamin E followed the same trend and reached a steady state by two weeks. Overall, it can be concluded that the diffusion of an oil-based fluid into polyethylene not only increases the oxidative and chemical stability of polyethylene but also adds additional functionality (e.g. radiopacity) providing a more suitable material for long–term medical applications. SAGE Publications 2020-12-26 2021-04 /pmc/articles/PMC8013815/ /pubmed/33356787 http://dx.doi.org/10.1177/0885328220977353 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Biomaterials Processing
Zaribaf, Fedra P
Gill, Harinderjit S
Pegg, Elise C
Chemical stability of oil-infused polyethylene
title Chemical stability of oil-infused polyethylene
title_full Chemical stability of oil-infused polyethylene
title_fullStr Chemical stability of oil-infused polyethylene
title_full_unstemmed Chemical stability of oil-infused polyethylene
title_short Chemical stability of oil-infused polyethylene
title_sort chemical stability of oil-infused polyethylene
topic Biomaterials Processing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013815/
https://www.ncbi.nlm.nih.gov/pubmed/33356787
http://dx.doi.org/10.1177/0885328220977353
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