CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

Circadian rhythms are a pervasive property of mammalian cells, tissues and behaviour, ensuring physiological adaptation to solar time. Models of cellular timekeeping revolve around transcriptional feedback repression, whereby CLOCK and BMAL1 activate the expression of PERIOD (PER) and CRYPTOCHROME (...

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Detalles Bibliográficos
Autores principales: Putker, Marrit, Wong, David C S, Seinkmane, Estere, Rzechorzek, Nina M, Zeng, Aiwei, Hoyle, Nathaniel P, Chesham, Johanna E, Edwards, Mathew D, Feeney, Kevin A, Fischer, Robin, Peschel, Nicolai, Chen, Ko‐Fan, Vanden Oever, Michael, Edgar, Rachel S, Selby, Christopher P, Sancar, Aziz, O’Neill, John S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013833/
https://www.ncbi.nlm.nih.gov/pubmed/33491228
http://dx.doi.org/10.15252/embj.2020106745

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