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Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival?

Influenza virus and coronavirus pandemics regularly sweep the globe, at great cost of health and economy. Our aim was to conduct a PubMed search for autopsy studies on influenza and coronavirus to investigate the contribution of autopsies during pandemics, focussing on autopsy methods and procedures...

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Autores principales: Khatam‐Lashgari, Apameh, Henningsen, Mikkel Jon, Olsen, Kristine Boisen, Jacobsen, Christina, Hasselby, Jane Preuss, Colville‐Ebeling, Bonnie, Banner, Jytte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013917/
https://www.ncbi.nlm.nih.gov/pubmed/33645838
http://dx.doi.org/10.1111/apm.13111
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author Khatam‐Lashgari, Apameh
Henningsen, Mikkel Jon
Olsen, Kristine Boisen
Jacobsen, Christina
Hasselby, Jane Preuss
Colville‐Ebeling, Bonnie
Banner, Jytte
author_facet Khatam‐Lashgari, Apameh
Henningsen, Mikkel Jon
Olsen, Kristine Boisen
Jacobsen, Christina
Hasselby, Jane Preuss
Colville‐Ebeling, Bonnie
Banner, Jytte
author_sort Khatam‐Lashgari, Apameh
collection PubMed
description Influenza virus and coronavirus pandemics regularly sweep the globe, at great cost of health and economy. Our aim was to conduct a PubMed search for autopsy studies on influenza and coronavirus to investigate the contribution of autopsies during pandemics, focussing on autopsy methods and procedures and the role of autopsy findings in pandemics. The retrieved autopsy studies generally relied on microscopy, polymerase chain reaction (PCR), immunostaining and electron microscopy. Most were small and reported on lung effects, including diffuse alveolar damage (DAD), pneumonia and tracheobronchitis. Antibiotic therapy has diminished a role for bacterial pneumonia, whereas obesity is an emerging risk factor. Autopsy studies have provided new insights into coronavirus disease 2019 (COVID‐19) treatments like anti‐coagulative therapy. Unfortunately, autopsies during pandemics are hampered by lack of guidelines, facilities and expertise for handling potentially infectious corpses and by widely varying recommendations for personal protective equipment and procedures. The Department of Forensic Pathology, at the Forensic Institute, at the University of Copenhagen in Denmark has, in collaboration with the Department of Pathology, Rigshospitalet, Copenhagen, initiated a prospective observational study on COVID‐19‐related deaths encompassing postmortem imaging, standardized autopsy procedures/reporting and extensive tissue sampling for histological, chemical, microbiological and genetic analysis. The study involves a diverse array of research groups at the University of Copenhagen, and the clinical field.
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spelling pubmed-80139172021-04-01 Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival? Khatam‐Lashgari, Apameh Henningsen, Mikkel Jon Olsen, Kristine Boisen Jacobsen, Christina Hasselby, Jane Preuss Colville‐Ebeling, Bonnie Banner, Jytte APMIS Review Articles Influenza virus and coronavirus pandemics regularly sweep the globe, at great cost of health and economy. Our aim was to conduct a PubMed search for autopsy studies on influenza and coronavirus to investigate the contribution of autopsies during pandemics, focussing on autopsy methods and procedures and the role of autopsy findings in pandemics. The retrieved autopsy studies generally relied on microscopy, polymerase chain reaction (PCR), immunostaining and electron microscopy. Most were small and reported on lung effects, including diffuse alveolar damage (DAD), pneumonia and tracheobronchitis. Antibiotic therapy has diminished a role for bacterial pneumonia, whereas obesity is an emerging risk factor. Autopsy studies have provided new insights into coronavirus disease 2019 (COVID‐19) treatments like anti‐coagulative therapy. Unfortunately, autopsies during pandemics are hampered by lack of guidelines, facilities and expertise for handling potentially infectious corpses and by widely varying recommendations for personal protective equipment and procedures. The Department of Forensic Pathology, at the Forensic Institute, at the University of Copenhagen in Denmark has, in collaboration with the Department of Pathology, Rigshospitalet, Copenhagen, initiated a prospective observational study on COVID‐19‐related deaths encompassing postmortem imaging, standardized autopsy procedures/reporting and extensive tissue sampling for histological, chemical, microbiological and genetic analysis. The study involves a diverse array of research groups at the University of Copenhagen, and the clinical field. John Wiley and Sons Inc. 2021-03-01 2021-07 /pmc/articles/PMC8013917/ /pubmed/33645838 http://dx.doi.org/10.1111/apm.13111 Text en © 2021 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Medical Microbiology and Pathology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Khatam‐Lashgari, Apameh
Henningsen, Mikkel Jon
Olsen, Kristine Boisen
Jacobsen, Christina
Hasselby, Jane Preuss
Colville‐Ebeling, Bonnie
Banner, Jytte
Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival?
title Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival?
title_full Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival?
title_fullStr Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival?
title_full_unstemmed Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival?
title_short Autopsies in pandemics – a perspective on barriers and benefits. Is it time for a revival?
title_sort autopsies in pandemics – a perspective on barriers and benefits. is it time for a revival?
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8013917/
https://www.ncbi.nlm.nih.gov/pubmed/33645838
http://dx.doi.org/10.1111/apm.13111
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