Sustained cellular immunity in adults recovered from mild COVID‐19

Transient lymphocytopenia is frequently observed in acute phase of coronavirus disease 2019 (COVID‐19). It remains a concern whether impairment of cellular immunity may be retained after COVID‐19. Here, we demonstrate by extensive lymphocyte profiling in 44 adults after mild COVID‐19 that cellular i...

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Autores principales: Rank, Andreas, Löhr, Phillip, Hoffmann, Reinhard, Ebigbo, Alanna, Grützner, Stefanie, Schmid, Christoph, Claus, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
COVID‐19 Fast Track
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014675/
https://www.ncbi.nlm.nih.gov/pubmed/33522107
http://dx.doi.org/10.1002/cyto.a.24309
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author Rank, Andreas
Löhr, Phillip
Hoffmann, Reinhard
Ebigbo, Alanna
Grützner, Stefanie
Schmid, Christoph
Claus, Rainer
author_facet Rank, Andreas
Löhr, Phillip
Hoffmann, Reinhard
Ebigbo, Alanna
Grützner, Stefanie
Schmid, Christoph
Claus, Rainer
author_sort Rank, Andreas
collection PubMed
description Transient lymphocytopenia is frequently observed in acute phase of coronavirus disease 2019 (COVID‐19). It remains a concern whether impairment of cellular immunity may be retained after COVID‐19. Here, we demonstrate by extensive lymphocyte profiling in 44 adults after mild COVID‐19 that cellular immunity is not fundamentally altered in convalescent patients. Except for increased activated CD8+ lymphocytes, total counts of B, T, and NK cells and their subsets did not differ significantly between patients after COVID‐19 and healthy controls after a median of 27 days (range 13–45) suggesting no residual cellular immune deficiency after recovery from mild COVID‐19.
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spelling pubmed-80146752021-04-01 Sustained cellular immunity in adults recovered from mild COVID‐19 Rank, Andreas Löhr, Phillip Hoffmann, Reinhard Ebigbo, Alanna Grützner, Stefanie Schmid, Christoph Claus, Rainer Cytometry A COVID‐19 Fast Track Transient lymphocytopenia is frequently observed in acute phase of coronavirus disease 2019 (COVID‐19). It remains a concern whether impairment of cellular immunity may be retained after COVID‐19. Here, we demonstrate by extensive lymphocyte profiling in 44 adults after mild COVID‐19 that cellular immunity is not fundamentally altered in convalescent patients. Except for increased activated CD8+ lymphocytes, total counts of B, T, and NK cells and their subsets did not differ significantly between patients after COVID‐19 and healthy controls after a median of 27 days (range 13–45) suggesting no residual cellular immune deficiency after recovery from mild COVID‐19. John Wiley & Sons, Inc. 2021-01-31 2021-05 /pmc/articles/PMC8014675/ /pubmed/33522107 http://dx.doi.org/10.1002/cyto.a.24309 Text en © 2021 The Authors. Cytometry Part A published by Wiley Periodicals LLC. on behalf of International Society for Advancement of Cytometry. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle COVID‐19 Fast Track
Rank, Andreas
Löhr, Phillip
Hoffmann, Reinhard
Ebigbo, Alanna
Grützner, Stefanie
Schmid, Christoph
Claus, Rainer
Sustained cellular immunity in adults recovered from mild COVID‐19
title Sustained cellular immunity in adults recovered from mild COVID‐19
title_full Sustained cellular immunity in adults recovered from mild COVID‐19
title_fullStr Sustained cellular immunity in adults recovered from mild COVID‐19
title_full_unstemmed Sustained cellular immunity in adults recovered from mild COVID‐19
title_short Sustained cellular immunity in adults recovered from mild COVID‐19
title_sort sustained cellular immunity in adults recovered from mild covid‐19
topic COVID‐19 Fast Track
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014675/
https://www.ncbi.nlm.nih.gov/pubmed/33522107
http://dx.doi.org/10.1002/cyto.a.24309
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