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Association between periodontitis and severity of COVID‐19 infection: A case–control study

AIM: COVID‐19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID‐19 complications. MATERIALS AND METHODS: A case–contro...

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Autores principales: Marouf, Nadya, Cai, Wenji, Said, Khalid N., Daas, Hanin, Diab, Hanan, Chinta, Venkateswara Rao, Hssain, Ali Ait, Nicolau, Belinda, Sanz, Mariano, Tamimi, Faleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014679/
https://www.ncbi.nlm.nih.gov/pubmed/33527378
http://dx.doi.org/10.1111/jcpe.13435
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author Marouf, Nadya
Cai, Wenji
Said, Khalid N.
Daas, Hanin
Diab, Hanan
Chinta, Venkateswara Rao
Hssain, Ali Ait
Nicolau, Belinda
Sanz, Mariano
Tamimi, Faleh
author_facet Marouf, Nadya
Cai, Wenji
Said, Khalid N.
Daas, Hanin
Diab, Hanan
Chinta, Venkateswara Rao
Hssain, Ali Ait
Nicolau, Belinda
Sanz, Mariano
Tamimi, Faleh
author_sort Marouf, Nadya
collection PubMed
description AIM: COVID‐19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID‐19 complications. MATERIALS AND METHODS: A case–control study was performed using the national electronic health records of the State of Qatar between February and July 2020. Cases were defined as patients who suffered COVID‐19 complications (death, ICU admissions or assisted ventilation), and controls were COVID‐19 patients discharged without major complications. Periodontal conditions were assessed using dental radiographs from the same database. Associations between periodontitis and COVID 19 complications were analysed using logistic regression models adjusted for demographic, medical and behaviour factors. RESULTS: In total, 568 patients were included. After adjusting for potential confounders, periodontitis was associated with COVID‐19 complication including death (OR = 8.81, 95% CI 1.00–77.7), ICU admission (OR = 3.54, 95% CI 1.39–9.05) and need for assisted ventilation (OR = 4.57, 95% CI 1.19–17.4). Similarly, blood levels of white blood cells, D‐dimer and C Reactive Protein were significantly higher in COVID‐19 patients with periodontitis. CONCLUSION: Periodontitis was associated with higher risk of ICU admission, need for assisted ventilation and death of COVID‐19 patients, and with increased blood levels of biomarkers linked to worse disease outcomes.
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spelling pubmed-80146792021-04-01 Association between periodontitis and severity of COVID‐19 infection: A case–control study Marouf, Nadya Cai, Wenji Said, Khalid N. Daas, Hanin Diab, Hanan Chinta, Venkateswara Rao Hssain, Ali Ait Nicolau, Belinda Sanz, Mariano Tamimi, Faleh J Clin Periodontol Periodontal Diseases AIM: COVID‐19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID‐19 complications. MATERIALS AND METHODS: A case–control study was performed using the national electronic health records of the State of Qatar between February and July 2020. Cases were defined as patients who suffered COVID‐19 complications (death, ICU admissions or assisted ventilation), and controls were COVID‐19 patients discharged without major complications. Periodontal conditions were assessed using dental radiographs from the same database. Associations between periodontitis and COVID 19 complications were analysed using logistic regression models adjusted for demographic, medical and behaviour factors. RESULTS: In total, 568 patients were included. After adjusting for potential confounders, periodontitis was associated with COVID‐19 complication including death (OR = 8.81, 95% CI 1.00–77.7), ICU admission (OR = 3.54, 95% CI 1.39–9.05) and need for assisted ventilation (OR = 4.57, 95% CI 1.19–17.4). Similarly, blood levels of white blood cells, D‐dimer and C Reactive Protein were significantly higher in COVID‐19 patients with periodontitis. CONCLUSION: Periodontitis was associated with higher risk of ICU admission, need for assisted ventilation and death of COVID‐19 patients, and with increased blood levels of biomarkers linked to worse disease outcomes. John Wiley and Sons Inc. 2021-02-15 2021-04 /pmc/articles/PMC8014679/ /pubmed/33527378 http://dx.doi.org/10.1111/jcpe.13435 Text en © 2021 The Authors. Journal of Clinical Periodontology published by John Wiley & Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Periodontal Diseases
Marouf, Nadya
Cai, Wenji
Said, Khalid N.
Daas, Hanin
Diab, Hanan
Chinta, Venkateswara Rao
Hssain, Ali Ait
Nicolau, Belinda
Sanz, Mariano
Tamimi, Faleh
Association between periodontitis and severity of COVID‐19 infection: A case–control study
title Association between periodontitis and severity of COVID‐19 infection: A case–control study
title_full Association between periodontitis and severity of COVID‐19 infection: A case–control study
title_fullStr Association between periodontitis and severity of COVID‐19 infection: A case–control study
title_full_unstemmed Association between periodontitis and severity of COVID‐19 infection: A case–control study
title_short Association between periodontitis and severity of COVID‐19 infection: A case–control study
title_sort association between periodontitis and severity of covid‐19 infection: a case–control study
topic Periodontal Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014679/
https://www.ncbi.nlm.nih.gov/pubmed/33527378
http://dx.doi.org/10.1111/jcpe.13435
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