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Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study

BACKGROUND: Norwegian hospitals have operated within capacity during the COVID‐19 pandemic. We present patient and management characteristics, and outcomes for the entire cohort of adult (>18 years) COVID‐19 patients admitted to Norwegian intensive care units (ICU) from 10 March to 19 June 2020....

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Autores principales: Laake, Jon H., Buanes, Eirik A., Småstuen, Milada C., Kvåle, Reidar, Olsen, Brita F., Rustøen, Tone, Strand, Kristian, Sørensen, Vibecke, Hofsø, Kristin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014826/
https://www.ncbi.nlm.nih.gov/pubmed/33501998
http://dx.doi.org/10.1111/aas.13785
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author Laake, Jon H.
Buanes, Eirik A.
Småstuen, Milada C.
Kvåle, Reidar
Olsen, Brita F.
Rustøen, Tone
Strand, Kristian
Sørensen, Vibecke
Hofsø, Kristin
author_facet Laake, Jon H.
Buanes, Eirik A.
Småstuen, Milada C.
Kvåle, Reidar
Olsen, Brita F.
Rustøen, Tone
Strand, Kristian
Sørensen, Vibecke
Hofsø, Kristin
author_sort Laake, Jon H.
collection PubMed
description BACKGROUND: Norwegian hospitals have operated within capacity during the COVID‐19 pandemic. We present patient and management characteristics, and outcomes for the entire cohort of adult (>18 years) COVID‐19 patients admitted to Norwegian intensive care units (ICU) from 10 March to 19 June 2020. METHODS: Data were collected from The Norwegian intensive care and pandemic registry (NIPaR). Demographics, co‐morbidities, management characteristics and outcomes are described. ICU length of stay (LOS) was analysed with linear regression, and associations between risk factors and mortality were quantified using Cox regression. RESULTS: In total, 217 patients were included. The male to female ratio was 3:1 and the median age was 63 years. A majority (70%) had one or more co‐morbidities, most frequently cardiovascular disease (39%), chronic lung disease (22%), diabetes mellitus (20%), and obesity (17%). Most patients were admitted for acute hypoxaemic respiratory failure (AHRF) (91%) and invasive mechanical ventilation (MV) was used in 86%, prone ventilation in 38% and 25% of patients received a tracheostomy. Vasoactive drugs were used in 79% and renal replacement therapy in 15%. Median ICU LOS and time of MV was 14.0 and 12.0 days. At end of follow‐up 45 patients (21%) were dead. Age, co‐morbidities and severity of illness at admission were predictive of death. Severity of AHRF and male gender were associated with LOS. CONCLUSIONS: In this national cohort of COVID‐19 patients, mortality was low and attributable to known risk factors. Importantly, prolonged length‐of‐stay must be taken into account when planning for resource allocation for any next surge.
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spelling pubmed-80148262021-04-01 Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study Laake, Jon H. Buanes, Eirik A. Småstuen, Milada C. Kvåle, Reidar Olsen, Brita F. Rustøen, Tone Strand, Kristian Sørensen, Vibecke Hofsø, Kristin Acta Anaesthesiol Scand Intensive Care and Physiology BACKGROUND: Norwegian hospitals have operated within capacity during the COVID‐19 pandemic. We present patient and management characteristics, and outcomes for the entire cohort of adult (>18 years) COVID‐19 patients admitted to Norwegian intensive care units (ICU) from 10 March to 19 June 2020. METHODS: Data were collected from The Norwegian intensive care and pandemic registry (NIPaR). Demographics, co‐morbidities, management characteristics and outcomes are described. ICU length of stay (LOS) was analysed with linear regression, and associations between risk factors and mortality were quantified using Cox regression. RESULTS: In total, 217 patients were included. The male to female ratio was 3:1 and the median age was 63 years. A majority (70%) had one or more co‐morbidities, most frequently cardiovascular disease (39%), chronic lung disease (22%), diabetes mellitus (20%), and obesity (17%). Most patients were admitted for acute hypoxaemic respiratory failure (AHRF) (91%) and invasive mechanical ventilation (MV) was used in 86%, prone ventilation in 38% and 25% of patients received a tracheostomy. Vasoactive drugs were used in 79% and renal replacement therapy in 15%. Median ICU LOS and time of MV was 14.0 and 12.0 days. At end of follow‐up 45 patients (21%) were dead. Age, co‐morbidities and severity of illness at admission were predictive of death. Severity of AHRF and male gender were associated with LOS. CONCLUSIONS: In this national cohort of COVID‐19 patients, mortality was low and attributable to known risk factors. Importantly, prolonged length‐of‐stay must be taken into account when planning for resource allocation for any next surge. John Wiley and Sons Inc. 2021-02-27 2021-05 /pmc/articles/PMC8014826/ /pubmed/33501998 http://dx.doi.org/10.1111/aas.13785 Text en © 2021 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Intensive Care and Physiology
Laake, Jon H.
Buanes, Eirik A.
Småstuen, Milada C.
Kvåle, Reidar
Olsen, Brita F.
Rustøen, Tone
Strand, Kristian
Sørensen, Vibecke
Hofsø, Kristin
Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study
title Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study
title_full Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study
title_fullStr Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study
title_full_unstemmed Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study
title_short Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study
title_sort characteristics, management and survival of icu patients with coronavirus disease‐19 in norway, march‐june 2020. a prospective observational study
topic Intensive Care and Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014826/
https://www.ncbi.nlm.nih.gov/pubmed/33501998
http://dx.doi.org/10.1111/aas.13785
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