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Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues

BACKGROUND: The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma. RESULTS: Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthm...

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Detalles Bibliográficos
Autores principales: Almohammai, Asheed, Rahbarghazi, Reza, Keyhanmanesh, Rana, Rezaie, Jafar, Ahmadi, Mahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015058/
https://www.ncbi.nlm.nih.gov/pubmed/33794910
http://dx.doi.org/10.1186/s12950-021-00275-7
Descripción
Sumario:BACKGROUND: The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma. RESULTS: Our finding showed an increase in the expression of IL-4 and the suppression of IL-10 in asthmatic lung tissues compared to the control samples (p < 0.05). Along with the promotion of IL-4, the protein level of TNF-α was induced, showing an active inflammatory status in OVA-sensitized rats. According to our data, the promotion of asthmatic responses increased exosome biogenesis indicated by increased CD63 levels and acetylcholine esterase activity compared to the normal condition (p < 0.05). CONCLUSION: Data suggest that the stimulation of inflammatory response in asthmatic rats could simultaneously increase the paracrine activity of pulmonary cells via the exosome biogenesis. Exosome biogenesis may correlate with the inflammatory response.