Potential Cancer- and Alzheimer’s Disease-Targeting Phosphodiesterase Inhibitors from Uvaria alba: Insights from In Vitro and Consensus Virtual Screening

[Image: see text] Inhibition of the major cyclic adenosine monophosphate-metabolizing enzyme PDE4 has shown potential for the discovery of drugs for cancer, inflammation, and neurodegenerative disorders such as Alzheimer’s disease. As a springboard to explore new anti-cancer and anti-Alzheimer’s che...

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Detalles Bibliográficos
Autores principales: Quimque, Mark Tristan, Notarte, Kin Israel, Letada, Arianne, Fernandez, Rey Arturo, Pilapil, Delfin Yñigo, Pueblos, Kirstin Rhys, Agbay, Jay Carl, Dahse, Hans-Martin, Wenzel-Storjohann, Arlette, Tasdemir, Deniz, Khan, Abbas, Wei, Dong-Qing, Gose Macabeo, Allan Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015132/
https://www.ncbi.nlm.nih.gov/pubmed/33817501
http://dx.doi.org/10.1021/acsomega.1c00137

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