CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts

BACKGROUND: Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower respiratory tract of patients with idiopathic pulmona...

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Detalles Bibliográficos
Autores principales: Nathan, Shyam, Zhang, Haijun, Andreoli, Mirko, Leopold, Philip L., Crystal, Ronald G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015171/
https://www.ncbi.nlm.nih.gov/pubmed/33794877
http://dx.doi.org/10.1186/s12931-021-01677-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015171/
https://www.ncbi.nlm.nih.gov/pubmed/33794877
http://dx.doi.org/10.1186/s12931-021-01677-0

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