Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells

Extracellular vesicles (EVs) mediate the cross‐talk between cancer cells and the cells of the surrounding Tumour Microenvironment (TME). Professional killer cells include Natural Killer (NK) cells and CD8+ Cytotoxic T‐lymphocytes (CTLs), which represent some of the most effective immune defense mech...

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Autores principales: Del Vecchio, Filippo, Martinez‐Rodriguez, Verena, Schukking, Monique, Cocks, Alexander, Broseghini, Elisabetta, Fabbri, Muller
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015281/
https://www.ncbi.nlm.nih.gov/pubmed/33815694
http://dx.doi.org/10.1002/jev2.12075
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author Del Vecchio, Filippo
Martinez‐Rodriguez, Verena
Schukking, Monique
Cocks, Alexander
Broseghini, Elisabetta
Fabbri, Muller
author_facet Del Vecchio, Filippo
Martinez‐Rodriguez, Verena
Schukking, Monique
Cocks, Alexander
Broseghini, Elisabetta
Fabbri, Muller
author_sort Del Vecchio, Filippo
collection PubMed
description Extracellular vesicles (EVs) mediate the cross‐talk between cancer cells and the cells of the surrounding Tumour Microenvironment (TME). Professional killer cells include Natural Killer (NK) cells and CD8+ Cytotoxic T‐lymphocytes (CTLs), which represent some of the most effective immune defense mechanisms against cancer cells. Recent evidence supports the role of EVs released by NK cells and CTLs in killing cancer cells, paving the road to a possible therapeutic role for such EVs. This review article provides the state‐of‐the‐art knowledge on the role of NK‐ and CTL‐derived EVs as anticancer agents, focusing on the different functions of different sub‐types of EVs. We also reviewed the current knowledge on the effects of cancer‐derived EVs on NK cells and CTLs, identifying areas for future investigation in the emerging new field of EV‐mediated immunotherapy of cancer.
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spelling pubmed-80152812021-04-02 Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells Del Vecchio, Filippo Martinez‐Rodriguez, Verena Schukking, Monique Cocks, Alexander Broseghini, Elisabetta Fabbri, Muller J Extracell Vesicles Review Articles Extracellular vesicles (EVs) mediate the cross‐talk between cancer cells and the cells of the surrounding Tumour Microenvironment (TME). Professional killer cells include Natural Killer (NK) cells and CD8+ Cytotoxic T‐lymphocytes (CTLs), which represent some of the most effective immune defense mechanisms against cancer cells. Recent evidence supports the role of EVs released by NK cells and CTLs in killing cancer cells, paving the road to a possible therapeutic role for such EVs. This review article provides the state‐of‐the‐art knowledge on the role of NK‐ and CTL‐derived EVs as anticancer agents, focusing on the different functions of different sub‐types of EVs. We also reviewed the current knowledge on the effects of cancer‐derived EVs on NK cells and CTLs, identifying areas for future investigation in the emerging new field of EV‐mediated immunotherapy of cancer. John Wiley and Sons Inc. 2021-04-01 2021-04 /pmc/articles/PMC8015281/ /pubmed/33815694 http://dx.doi.org/10.1002/jev2.12075 Text en © 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Del Vecchio, Filippo
Martinez‐Rodriguez, Verena
Schukking, Monique
Cocks, Alexander
Broseghini, Elisabetta
Fabbri, Muller
Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells
title Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells
title_full Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells
title_fullStr Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells
title_full_unstemmed Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells
title_short Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T‐cells and tumour cells
title_sort professional killers: the role of extracellular vesicles in the reciprocal interactions between natural killer, cd8+ cytotoxic t‐cells and tumour cells
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015281/
https://www.ncbi.nlm.nih.gov/pubmed/33815694
http://dx.doi.org/10.1002/jev2.12075
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