A fatal case of COVID-19-associated invasive pulmonary aspergillosis

A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day...

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Detalles Bibliográficos
Autores principales: Iwanaga, Yuto, Kawanami, Toshinori, Yamasaki, Kei, Sakakibara, Hideki, Ikushima, Issei, Ikegami, Hiroaki, Tahara, Masahiro, Akata, Kentaro, Mukae, Hiroshi, Yatera, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015426/
https://www.ncbi.nlm.nih.gov/pubmed/33867266
http://dx.doi.org/10.1016/j.jiac.2021.03.024
Descripción
Sumario:A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.

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