A fatal case of COVID-19-associated invasive pulmonary aspergillosis

A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day...

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Autores principales: Iwanaga, Yuto, Kawanami, Toshinori, Yamasaki, Kei, Sakakibara, Hideki, Ikushima, Issei, Ikegami, Hiroaki, Tahara, Masahiro, Akata, Kentaro, Mukae, Hiroshi, Yatera, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015426/
https://www.ncbi.nlm.nih.gov/pubmed/33867266
http://dx.doi.org/10.1016/j.jiac.2021.03.024
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author Iwanaga, Yuto
Kawanami, Toshinori
Yamasaki, Kei
Sakakibara, Hideki
Ikushima, Issei
Ikegami, Hiroaki
Tahara, Masahiro
Akata, Kentaro
Mukae, Hiroshi
Yatera, Kazuhiro
author_facet Iwanaga, Yuto
Kawanami, Toshinori
Yamasaki, Kei
Sakakibara, Hideki
Ikushima, Issei
Ikegami, Hiroaki
Tahara, Masahiro
Akata, Kentaro
Mukae, Hiroshi
Yatera, Kazuhiro
author_sort Iwanaga, Yuto
collection PubMed
description A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.
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spelling pubmed-80154262021-04-02 A fatal case of COVID-19-associated invasive pulmonary aspergillosis Iwanaga, Yuto Kawanami, Toshinori Yamasaki, Kei Sakakibara, Hideki Ikushima, Issei Ikegami, Hiroaki Tahara, Masahiro Akata, Kentaro Mukae, Hiroshi Yatera, Kazuhiro J Infect Chemother Case Report A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2021-07 2021-04-01 /pmc/articles/PMC8015426/ /pubmed/33867266 http://dx.doi.org/10.1016/j.jiac.2021.03.024 Text en © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Iwanaga, Yuto
Kawanami, Toshinori
Yamasaki, Kei
Sakakibara, Hideki
Ikushima, Issei
Ikegami, Hiroaki
Tahara, Masahiro
Akata, Kentaro
Mukae, Hiroshi
Yatera, Kazuhiro
A fatal case of COVID-19-associated invasive pulmonary aspergillosis
title A fatal case of COVID-19-associated invasive pulmonary aspergillosis
title_full A fatal case of COVID-19-associated invasive pulmonary aspergillosis
title_fullStr A fatal case of COVID-19-associated invasive pulmonary aspergillosis
title_full_unstemmed A fatal case of COVID-19-associated invasive pulmonary aspergillosis
title_short A fatal case of COVID-19-associated invasive pulmonary aspergillosis
title_sort fatal case of covid-19-associated invasive pulmonary aspergillosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015426/
https://www.ncbi.nlm.nih.gov/pubmed/33867266
http://dx.doi.org/10.1016/j.jiac.2021.03.024
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