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Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial
In a RCT of 63 patients with COPD, 12 weeks of ICS/LABA therapy downregulated bronchial epithelial expression of the SARS-CoV-2-related genes ACE2 and ADAM17 compared to LABA alone. This may have implications for COVID-19 susceptibility/severity in COPD. https://bit.ly/3vZnBVO
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Respiratory Society
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015643/ https://www.ncbi.nlm.nih.gov/pubmed/33795322 http://dx.doi.org/10.1183/13993003.00130-2021 |
| _version_ | 1783673723290648576 |
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| author | Milne, Stephen Li, Xuan Yang, Chen Xi Leitao Filho, Fernando Sergio Hernández Cordero, Ana I. Yang, Cheng Wei Tony Shaipanich, Tawimas van Eeden, Stephan F. Leung, Janice M. Lam, Stephen Sin, Don D. |
| author_facet | Milne, Stephen Li, Xuan Yang, Chen Xi Leitao Filho, Fernando Sergio Hernández Cordero, Ana I. Yang, Cheng Wei Tony Shaipanich, Tawimas van Eeden, Stephan F. Leung, Janice M. Lam, Stephen Sin, Don D. |
| author_sort | Milne, Stephen |
| collection | PubMed |
| description | In a RCT of 63 patients with COPD, 12 weeks of ICS/LABA therapy downregulated bronchial epithelial expression of the SARS-CoV-2-related genes ACE2 and ADAM17 compared to LABA alone. This may have implications for COVID-19 susceptibility/severity in COPD. https://bit.ly/3vZnBVO |
| format | Online Article Text |
| id | pubmed-8015643 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | European Respiratory Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80156432021-04-02 Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial Milne, Stephen Li, Xuan Yang, Chen Xi Leitao Filho, Fernando Sergio Hernández Cordero, Ana I. Yang, Cheng Wei Tony Shaipanich, Tawimas van Eeden, Stephan F. Leung, Janice M. Lam, Stephen Sin, Don D. Eur Respir J Agora In a RCT of 63 patients with COPD, 12 weeks of ICS/LABA therapy downregulated bronchial epithelial expression of the SARS-CoV-2-related genes ACE2 and ADAM17 compared to LABA alone. This may have implications for COVID-19 susceptibility/severity in COPD. https://bit.ly/3vZnBVO European Respiratory Society 2021-07-29 /pmc/articles/PMC8015643/ /pubmed/33795322 http://dx.doi.org/10.1183/13993003.00130-2021 Text en Copyright ©The authors 2021. https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
| spellingShingle | Agora Milne, Stephen Li, Xuan Yang, Chen Xi Leitao Filho, Fernando Sergio Hernández Cordero, Ana I. Yang, Cheng Wei Tony Shaipanich, Tawimas van Eeden, Stephan F. Leung, Janice M. Lam, Stephen Sin, Don D. Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial |
| title | Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial |
| title_full | Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial |
| title_fullStr | Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial |
| title_full_unstemmed | Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial |
| title_short | Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial |
| title_sort | inhaled corticosteroids downregulate sars-cov-2-related genes in copd: results from a randomised controlled trial |
| topic | Agora |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015643/ https://www.ncbi.nlm.nih.gov/pubmed/33795322 http://dx.doi.org/10.1183/13993003.00130-2021 |
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